A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle

ConclusionsThis study provides a minable data set for every human gene regarding its role in EBOV genome replication and transcription, shows that an FDA-approved drug targeting one of the identified pathways is highly efficacious in vitro, and demonstrates the power of life cycle modelling systems for conducting genome-wide host factor screens for BSL4 viruses.

http://link.springer.com/10.1186/s13073-018-0570-1

Source: Genome Medicine - August 7, 2018 Category: Genetics & Stem Cells Source Type: research