Recent developments in green membrane-based extraction techniques for pharmaceutical and biomedical analysis

Publication date: Available online 6 August 2018Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Hadi Tabani, Saeed Nojavan, Michal Alexovič, Ján SaboAbstractMonitoring of target analytes (e.g., pharmaceuticals, endogenous compounds) present in biological samples usually requires a preliminary step toward analyte isolation from surrounding matrix and enrichment for trace analysis. Evident developments have been recently made to introduce novel “green” analytical approaches (which keep the requirements of Green Analytical Chemistry – GAC) being effective, economical, eco-friendly, and amenable to hyphenated analytical instrumentations. Modern membrane-based extraction techniques provide the smart options against classical sample preparations e.g., liquid-liquid extraction (LLE).These approaches are more stable and allow trace determination of analytes in complex matrices (e.g., biological samples), with high extraction recovery and selectivity. Simultaneously, drawbacks of LLE such as large consumption of organic solvents and the need for tedious handling are eliminated.This paper thoroughly overviews important features and applications of membrane extraction techniques with special focus on pharmaceutical and biomedical analysis since 2013. Different driving forces of mass transfer across the membrane were summarized and membrane extraction-based techniques were described along with their advantages/disadvantages as well.
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research