S100B Suppression Alters Polarization of Infiltrating Myeloid-Derived Cells in Gliomas and Inhibits Tumor Growth

S100B, a member of the multigene family of Ca2+-binding proteins, is overexpressed by most malignant gliomas but its biological role in gliomagenesis is unclear. Recently, we demonstrated that low concentrations of S100B attenuated microglia activation through the induction of STAT3. Furthermore, S100B downregulation in a murine glioma model inhibited macrophage trafficking and tumor growth. Based on these observations, we hypothesized that S100B inhibitors may have antiglioma properties through modulation of tumor microenvironment.

Source: Cancer Letters - August 2, 2018 Category: Cancer & Oncology Authors: Hang Gao, Ian Y. Zhang, Leying Zhang, Yanyan Song, Shunan Liu, Hui Ren, Huili Liu, Hui Zhou, Yanping Su, Yihang Yang, Behnam Badie Tags: Original Articles Source Type: research