In Vivo Characterization of 4 68Ga-Labeled Multimeric RGD Peptides to Image {alpha}v{beta}3 Integrin Expression in 2 Human Tumor Xenograft Mouse Models

Conclusion: All tracers showed sufficient targeting of αvβ3 integrin expression to allow for tumor detection. Although the highest tumor uptake was found for 68Ga-FSC-(RGD)3 and 68Ga-THP-(RGD)3 in the SK-RC-52 and FaDu models, respectively, selection of the optimal tracer for specific diagnostic applications also depends on tumor-to-blood ratio and uptake in normal tissues; these factors should therefore also be considered.

Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Lobeek, D., Franssen, G. M., Ma, M. T., Wester, H.-J., Decristoforo, C., Oyen, W. J. G., Boerman, O. C., Terry, S. Y. A., Rijpkema, M. Tags: Basic Source Type: research