Primary Ciliary Dyskinesia: Longitudinal Study of Lung Disease by Ultrastructure Defect and Genotype.

CONCLUSIONS: Participants with IDA/MTD/CA defects, which included individuals with CCDC39 or CCDC40 mutations, had worse lung function and growth indices compared to those with ODA defects and DNAH5 mutations, respectively. The only group with a significant lung function decline over time were participants with IDA/MTD/CA defects. PMID: 30067075 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30067075?dopt=Abstract

Source: Am J Respir Crit Car... - August 1, 2018 Category: Intensive Care Authors: Davis SD, Rosenfeld M, Lee HS, Ferkol TW, Sagel SD, Dell SD, Milla C, Pittman JE, Shapiro AJ, Sullivan KM, Nykamp KR, Krischer JP, Zariwala MA, Knowles MR, Leigh MW, and Genetic Disorders of Mucociliary Clearance Consortium Tags: Am J Respir Crit Care Med Source Type: research

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