Reproducibility of PD-L1 immunohistochemistry interpretation across various types of genitourinary and head/neck carcinomas, antibody clones, and tissue types

Programmed death-ligand 1 (PD-L1) expression by tumor cells is a mechanism for downregulation of antitumor T cell responses and is a target for immunotherapy in various cancers. PD-L1 status as a predictor of treatment response has led to the development of multiple platforms with different reference cutoffs. We studied 128 cases of genitourinary and head/neck carcinomas, aiming to assess the frequency of PD-L1 positivity, interobserver reliability of PD-L1 interpretation and the concordance of PD-L1 scoring between small samples from tissue microarray (TMA) and whole sections (WS) using SP263 and SP142 clones.
Source: Human Pathology - Category: Pathology Authors: Tags: Original Contributions Source Type: research