Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI

Conclusions
AKI-induced urinary TIMP2/IGFBP7 elevations are not due to stress-induced gene transcription. Rather, increased filtration, decreased tubule reabsorption, and proximal tubule cell TIMP2/IGFBP7 urinary leakage seem to be the most likely mechanisms.

Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Johnson, A. C. M., Zager, R. A. Tags: Basic Research Source Type: research