Implications of an admixed Brazilian population in schizophrenia polygenic risk score

The Psychiatric Genomics Consortium (PGC) has implemented a tool, called Polygenic Risk Score (PRS), which compiles data from hundreds to millions of common variants into a single measure, making it a valuable instrument to investigate the genetic risk of complex diseases, like schizophrenia (SCZ) (Dudbridge, 2013; Purcell et al., 2009). To calculate the SCZ-PRS, a reference sample must be defined, but most subjects in currently available samples are Caucasian, and doubts remain about the reliability and efficiency of SCZ-PRS in admixed samples (Birnbaum and Weinberger, 2017; Vassos et al., 2017).
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research