Cbt modulates Foxo activation by positively regulating insulin signaling in Drosophila embryos

In this study, we used genomic approaches to identify genes regulated by Cbt as well as its direct targets during late embryogenesis. Our results reveal a complex transcriptional circuit downstream of Cbt and evidence that it is functionally related with the Insulin/insulin-like growth factor signaling pathway. In this context, Cbt may act as a positive regulator of the pathway, leading to the repression of Foxo activity. Our results also suggest that the DC defects observed in cbt embryos could be partially due to Foxo overactivation and that a regulatory feedback loop between Foxo and Cbt may be operating in the DC context.

Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 26, 2018 Category: Genetics & Stem Cells Source Type: research