The measurement of Protein Synthesis for Assessing Proteostasis in Studies of Slowed Aging.

The measurement of Protein Synthesis for Assessing Proteostasis in Studies of Slowed Aging.
Ageing Res Rev. 2014 Oct 1;
Authors: Miller BF, Drake JC, Naylor B, Price JC, Hamilton KL
Abstract
Slowing the aging process can reduce the risk for multiple chronic diseases simultaneously. It is increasingly recognized that maintaining protein homeostasis (or proteostasis) is important for slowing the aging process. Since proteostasis is a dynamic process, monitoring it is not a simple task and requires use of appropriate methods. This review will introduce methods to assess protein and DNA synthesis using deuterium oxide (D2O), and how protein and DNA synthesis outcomes provide insight into proteostatic mechanisms. Finally, we provide a discussion on how these assessments of protein and DNA synthesis are "mechanistic" investigations and provide an appropriate framework for the further development of slowed aging treatments.
PMID: 25283966 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - October 1, 2014 Category: Genetics & Stem Cells Authors: Miller BF, Drake JC, Naylor B, Price JC, Hamilton KL Tags: Ageing Res Rev Source Type: research