Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) o...

Source: Arthritis Research and Therapy - July 20, 2018 Category: Rheumatology Authors: Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steink ühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten and Timothy R. D. J. Radstake Tags: Research article Source Type: research