Application of a Cryogel-Coated Prosthetic Vascular Graft Material for Delivery of Targeted Gene Therapies in a Rabbit Model

The long-term success of prosthetic vascular grafts for revascularization in peripheral arterial disease is limited by the development of anastomotic neointimal hyperplasia. We have constructed a bioactive prosthetic graft material by coating polyethylene terephthalate (PET) with an antithrombogenic cryogel polymer layer capable of delivering biologic agents in vitro. Our goal was to evaluate our hybrid prosthetic graft material in vivo using a rabbit carotid interposition bypass model.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2018 Eastern Vascular Society Annual Meeting Source Type: research