Ambroxol induces autophagy and potentiates Rifampin antimycobacterial activity.

Ambroxol induces autophagy and potentiates Rifampin antimycobacterial activity.
Antimicrob Agents Chemother. 2018 Jul 16;:
Authors: Choi SW, Gu Y, Peters RS, Salgame P, Ellner JJ, Timmins GS, Deretic V
Abstract
Host-directed therapy (HDT) in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis A lead compound, ambroxol emerged from a screen for autophagy-inducing drugs. Ambroxol, at clinically-relevant relevant doses, induced autophagy in vitro and in vivo, and promoted mycobacterial killing in macrophages. Ambroxol also potentiated rifampin activity in a murine tuberculosis model.
PMID: 30012752 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - July 16, 2018 Category: Microbiology Authors: Choi SW, Gu Y, Peters RS, Salgame P, Ellner JJ, Timmins GS, Deretic V Tags: Antimicrob Agents Chemother Source Type: research