A plausible model correlates prebiotic peptide synthesis with the primordial genetic code.

A plausible model correlates prebiotic peptide synthesis with the primordial genetic code.
Chem Commun (Camb). 2018 Jul 17;:
Authors: Ying J, Fu S, Li X, Feng L, Xu P, Liu Y, Gao X, Zhao Y
Abstract
Aminoacyladenylates (5'-aa-AMPs) are key intermediates in peptide synthesis. Here we report analogs of 5'-aa-AMPs, namely nucleotide amidates (aa-N-NMPs), obtained under Hadean conditions. Significantly, dipeptides were detected from the above reactions and their yields varied with different nucleosides through the formation of different aa-N-NMPs. This model provides both prebiotic peptides and the primordial version of the genetic code through reactions that occurred under potentially prebiotic conditions.
PMID: 30014068 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 17, 2018 Category: Chemistry Authors: Ying J, Fu S, Li X, Feng L, Xu P, Liu Y, Gao X, Zhao Y Tags: Chem Commun (Camb) Source Type: research