Roche lauds new flu drug trial as Tamiflu suffers generics hit

Swiss drugmaker Roche's hopes of regaining ground in the influenza market have been boosted after a late-stage study showed its investigational drug baloxavir marboxil reduced symptoms in people at high risk of complications.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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ConclusionsDue to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
In this study, we examined the potential usefulness of having separate waiting rooms by conducting a questionnaire survey on the structure of the pharmacy waiting room and investigating the visiting situation for influenza-infected pediatric patients from a record of the medicines they received. As a result of the questionnaire tabulated from guardians of 385 pediatric patients who first visited a pharmacy with separate waiting rooms, 70% of the pediatric patients concluded that having separate waiting rooms would be satisfactory. In addition, the possible risk of horizontal transmission of influenza was supposed to be red...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Authors: Valentino S, Suit L Abstract Background: The community college student is not currently armed with the resources or prevention information regarding influenza. Less than twenty percent of the college population receives influenza immunization annually.Purpose: The purpose of the project was to evaluate if an evidenced-based influenza and vaccine education intervention will affect nursing students' intent to vaccinate for influenza by increasing knowledge of the influenza vaccine using Zingg and Siegrist's Knowledge Scale.Methods: Participants were recruited voluntarily from their attendance at orientation ...
Source: Journal of Community Health Nursing - Category: Nursing Tags: J Community Health Nurs Source Type: research
Abstract An outbreak of 2019-nCoV infection in China has spread across the world. No specific antiviral drugs have been approved for the treatment of COVID-2019. In addition to the recommended antiviral drugs such as interferon-ɑ, lopinavir/ritonavir, ribavirin, and chloroquine phosphate, some clinical trials focusing on virus RNA dependent RNA polymerase (RdRp) inhibitors have been registered and initiated. Favipiravir, a purine nucleic acid analog and potent RdRp inhibitor approved for use in influenza, is also considered in several clinical trials. Herein, we summarized the pharmacokinetic characteristics of f...
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research
AbstractThe use of the nanocapsulated adjuvant Sapomax increased the expression of innate immunity genes (H2Q10, Ddx58, Tyk2, Tlr3, Tlr7, and TNF) responsible for the primary recognition of influenza virus, i.e., those belonging to the RLR and TLR families; genes involved in stimulating the production of type I and III IFN and pro-inflammatory cytokines; and Th1 and Th2 cellular immunity genes (Ccr4, Ccr5, IFN γ, IL-2, IL-4, and IL-10) responsible for triggering regulatory immune mechanisms in the cell. The high immunological activity of the plant-derived nanocapsulated adjuvant Sapomax may be used to enhance the efficacy of vaccines.
Source: Archives of Virology - Category: Virology Source Type: research
Tate : Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection. However, severe IAV infections in humans are characterised by excessive inflammation and tissue damage, often leading to fatal disease. While the molecular mechanisms involved in the induction of inflammation during IAV infection have been well studied, the pathways involved in IAV-induced cell death and their impact on immunopathology have not been fully elucidated. There is increasing evidence of ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
The reassortant vaccine strain of live attenuated influenza vaccine inherits temperature sensitivity and areactogenicity from cold-adapted attenuated master donor virus. In Russia, B/ USSR/60/69 master donor virus (B60) is currently in use for the preparation of live attenuated type B influenza vaccine candidates. Trivalent live attenuated influenza vaccine based on A/ Leningrad/134/17/57 and B60 are licensed for the use in Russia for single dose vaccination of adults and children over 3 years. B/Leningrad/14/17/55 (B14) cold-adapted virus is a backup master donor virus for live attenuated type B influenza vaccine. Accordi...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
If you have no symptoms of the coronavirus, should you wear a mask? It’s one of the most-asked questions during this pandemic, and until recently, one of the most easily answered—if you follow the guidance of the U.S. Centers for Disease Control and Prevention. The CDC’s answer, up until April 3? No. According to its initial guidelines, outside of health care settings, face masks should only be worn by people who are sick or who are caring for someone who is sick (when the person who is sick can’t wear a mask). A mask helps capture some of an ill person’s cough particles that might otherwise s...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Abstract Despite numerous studies evaluating influenza and Respiratory Syncytial Virus (RSV), there is still a lack of knowledge about them, especially in tropical countries. We compared the relative importance of respiratory viruses by examining their spatiotemporal patterns, age-specific hospitalization data and mortality data for 2007-2012 obtained from official sources. The data were aggregated into "respiratory infection seasonal zones" formed combining states that had similar seasonal patterns of pneumonia and influenza (P&I). Equatorial-North where P&I peaks in the middle of the year, Equatorial-S...
Source: An Acad Bras Cienc - Category: Science Authors: Tags: An Acad Bras Cienc Source Type: research
This article is republished from The Conversation under a Creative Commons license. Read the original article. The post Coronavirus: Country Comparisons are Pointless Unless We Account for These Biases in Testing appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health TerraViva United Nations Coronavirus Source Type: news
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