TP53 mutation and complex karyotype portends a dismal prognosis in mantle cell lymphoma

The predictive value of TP53 mutation (TP53mut) and complex karyotype (CK) was analyzed in 74 mantle cell lymphoma (MCL) patients. CK and TP53mut were predictors of inferior PFS and OS, independent of age and MIPI. The combination of TP53mut and CK status stratifies the patient population into three prognostic groups (p

Source: Clinical Lymphoma, Myeloma and Leukemia - July 15, 2018 Category: Hematology Authors: Ale š Obr, Vít Procházka, Andrea Jirkuvová, Helena Urbánková, Eva Kriegova, Petra Schneiderová, Michaela Vatolíková, Tomáš Papajík Tags: Original Study Source Type: research