Experimental set-up for FLASH proton irradiation of small animals using a clinical system

Recent in vivo investigations have shown that short pulses of electrons at very high dose-rate (FLASH) are less harmful to healthy tissues, but just as efficient as conventional dose-rate radiation to inhibit tumor growth. In view of the potential clinical value of FLASH and the availability of modern proton therapy infrastructures to achieve this goal, we herein describe a series of technological developments required to investigate the biology of FLASH irradiation, using a commercially available clinical proton therapy system.

Source: International Journal of Radiation Oncology * Biology * Physics - July 12, 2018 Category: Radiology Authors: Annalisa Patriarca, Charles Fouillade, Michel Auger, Fr édéric Martin, Frédéric Pouzoulet, Catherine Nauraye, Sophie Heinrich, Vincent Favaudon, Samuel Meyroneinc, Rémi Dendale, Alejandro Mazal, Philip Poortmans, Pierre Verrelle, Ludovic De Marzi Tags: Biology Contribution Source Type: research