Echinocandin treatment of Candida albicans biofilms enhances neutrophil extracellular trap (NET) formation.

Echinocandin treatment of Candida albicans biofilms enhances neutrophil extracellular trap (NET) formation.
Antimicrob Agents Chemother. 2018 Jul 09;:
Authors: Hoyer AR, Johnson CJ, Hoyer MR, Kernien JF, Nett JE
Abstract
The nosocomial pathogen Candida albicans forms biofilms on medical devices that persist in the face of antifungals and host defenses. Echinocandins, the most effective anti-biofilm drugs, have recently been shown to augment the activity of neutrophils against biofilms through an unknown mechanism. Here we show that treatment of C. albicans biofilms with sub-inhibitory concentrations of echinocandins promotes the formation of neutrophil extracellular traps (NETs), structures of DNA, histones, and antimicrobial proteins with antifungal activity.
PMID: 29987146 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - July 9, 2018 Category: Microbiology Authors: Hoyer AR, Johnson CJ, Hoyer MR, Kernien JF, Nett JE Tags: Antimicrob Agents Chemother Source Type: research