Emerging role of lncRNAs in systemic lupus erythematosus

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Chan-Na Zhao, Yan-Mei Mao, Li-Na Liu, Xiao-Mei Li, De-Guang Wang, Hai-Feng PanAbstractLong non-coding RNAs (lncRNAs), defined as ≥200 base pairs in length but have little translation potential, play a key role in imprinting control, immune cell differentiation, apoptosis and immune responses. Recently, many potential lncRNAs have been revealed to contribute to a new layer of molecular regulation of systemic lupus erythematosus (SLE). Immune-related functional lncRNAs may serve as novel therapeutic targets and disease biomarkers to provide potential support for clinic treatment in this disease. In this review, we will briefly introduce the identification, biogenesis and functions of lncRNAs, and summarize recent advance in the role of lncRNAs in SLE.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 14 August 2018Source: Autoimmunity ReviewsAuthor(s): Kassem Sharif, Abdulla Watad, Louis Coplan, Benjamin Lichtbroun, Alec Krosser, Michael Lichtbroun, Nicola Luigi Bragazzi, Howard Amital, Arnon Afek, Yehuda ShoenfeldAbstractStress is defined as the pscyophysiological reaction in which the steady state is disturbed or threatened. Stress is not always perceived as a negative response. Stress results when environmental demands exceed an individuals' adaptive capacities. Autoimmune diseases are heterogeneous group of chronic diseases which occur secondary to loss of self antigen tolerance. ...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ConclusionsSerum LRG might be a biomarker for estimating SLE disease activity.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Dermatologic Therapy, EarlyView.
Source: Dermatologic Therapy - Category: Dermatology Authors: Source Type: research
Authors: Froelich MF, Stintzing S, Kumbrink J, Grünewald TGP, Mansmann U, Heinemann V, Kirchner T, Jung A Abstract Skin toxicity (ST) is a frequent adverse effect (AE) in anti-epidermal growth factor receptor (EGFR)-targeted treatment of metastatic colorectal cancer (mCRC) resulting in decreased quality of life and problems in clinical management. We wanted to identify biomarkers predicting ST in this setting and focused on 70 DNA polymorphisms associated with acne, the (immunoglobulin fragment crystallizable region) Fcγ-receptor pathway, and systemic lupus erythematosus (SLE) applying next-generation-se...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
ConclusionsThis case highlights a rare late dermatologic presentation of antiphospholipid syndrome, which responded poorly to conventional anticoagulation with warfarin. Current management is limited to experimental therapies and the role of newer anticoagulants is still unknown.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Immunotherapy, Ahead of Print.
Source: Immunotherapy - Category: Allergy & Immunology Authors: Source Type: research
AbstractPurpose of ReviewLupus nephritis is a frequent complication of systemic lupus erythematosus and is more common and severe in children. This is a disease of the immune system characterized by T cell, B cell, and complement activation, as well as immune complex formation and deposition. The introduction of steroids and later cyclophosphamide transformed lupus nephritis from a fatal to a treatable condition. However, the standard therapies currently used for treatment carry significant toxicity and chronic kidney disease still remains a far too frequent outcome. To address these issues, we will review current and emer...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
Conclusion: ICA aided in identifying the weak antibodies that were probably diluted in the mixing step. There is no gold standard test for the diagnosis of APS, and LAC detection still requires standardization of technique and interpretation.RESUMO Introdu ção: Trombofilia é a suscetibilidade à trombose, de natureza genética, adquirida ou mista. Entre as causas adquiridas, destaca-se a síndrome do anticorpo antifosfolípide (SAF) - doença autoimune caracterizada por anticorpos antifosfolípides, eventos trombóticos ou perda gestacional recorre nte. O diagn...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
(American College of Rheumatology) The American College of Rheumatology's Collaborative Initiatives department has received two grants from the Office of Minority Health to support the development of programs that aim to increase the recruitment and enrollment in clinical trials of minority populations affected by lupus.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
dling F Abstract INTRODUCTION:  Systemic lupus erythematodes (SLE) represents an autoimmune disease with a highly variable clinical course affecting numerous organs. Hepatic manifestation seems to be rare. It is not clear whether hepatic disease in SLE is of any prognostic importance or whether it correlates with disease activity. METHODS:  Our patient cohort included 172 patients with proven SLE, all treated at Bogenhausen Hospital between 01.2009 and 12.2015. Retrospectively, all admissions as inpatients and outpatients were analyzed (n = 671; mean 3.9 per patient). Liver damage was diagnosed ...
Source: Zeitschrift fur Gastroenterologie - Category: Gastroenterology Authors: Tags: Z Gastroenterol Source Type: research
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