Emerging role of lncRNAs in systemic lupus erythematosus

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Chan-Na Zhao, Yan-Mei Mao, Li-Na Liu, Xiao-Mei Li, De-Guang Wang, Hai-Feng PanAbstractLong non-coding RNAs (lncRNAs), defined as ≥200 base pairs in length but have little translation potential, play a key role in imprinting control, immune cell differentiation, apoptosis and immune responses. Recently, many potential lncRNAs have been revealed to contribute to a new layer of molecular regulation of systemic lupus erythematosus (SLE). Immune-related functional lncRNAs may serve as novel therapeutic targets and disease biomarkers to provide potential support for clinic treatment in this disease. In this review, we will briefly introduce the identification, biogenesis and functions of lncRNAs, and summarize recent advance in the role of lncRNAs in SLE.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

Related Links:

CONCLUSION: Once considered extremely rare, AMIC seems to be underrecognized, probably because of the false attribution of heart failure or hypertrophy to other causes. Certain biomarkers (cTnI, BNP) and imaging findings may lead to early diagnosis and enhance survival. PMID: 30323009 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
CONCLUSION: Results suggest that both staining approaches detect Treg differently and also that Treg play different role in pathogenesis of SLE and RA. PMID: 30325682 [PubMed - as supplied by publisher]
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Contributors : Irina Raykhel ; Johanna MyllyharjuSeries Type : Expression profiling by arrayOrganism : Canis lupus familiarisNo one pathway was identified in up- and downregulated genes profile in HIF2A KD Madin-Darby canine kidney epithelial cells (MDCKII) in normoxic condition.We used microarray to study the differential expression of genes in HIF2A knockdown versus WT Madin-Darby canine kidney epithelial cells (MDCKII)
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Canis lupus familiaris Source Type: research
. Harnett William Harnett Parasitic helminths and their isolated secreted products show promise as novel treatments for allergic and autoimmune conditions in humans. Foremost amongst the secreted products is ES-62, a glycoprotein derived from Acanthocheilonema viteae, a filarial nematode parasite of gerbils, which is anti-inflammatory by virtue of covalently-attached phosphorylcholine (PC) moieties. ES-62 has been found to protect against disease in mouse models of rheumatoid arthritis, systemic lupus erythematosus, and airway hyper-responsiveness. Furthermore, novel PC-based synthetic small molecule analogues (SMAs)...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In conclusion, CD11b+Gr1+ cells increased in the early stages of the lupus progression and mTOR pathway was critical for CD11b+Gr1+ cells in lupus development, suggesting the changes of inflammation-induced CD11b+Gr1+ cells initate lupus development. We also provide evidence for the first time that INK128, a second generation mTOR inhibitor, has a good therapeutic action on lupus development by regulating CD11b+Gr1+ cells.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
We present the case of a 34-year-old woman (gravida 2, para 1) who underwent a lower-segment cesarean section at 34 weeks and 6 days of gestation because she had developed preeclampsia and nephrotic syndrome. The concomitant presence of significant hypoproteinemia, hypoalbuminemia, uremia, elevated creatinine serum levels, hyperuricemia and hypertriglyceridemia is indicative of impaired renal function and nephrotic syndrome. This woman was diagnosed with systemic lupus erythematosus nephritis. It is imperative for clinicians to investigate the exact pathophysiological causes of nephrotic syndrome with onset in the puer...
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
This study aims to analyze the associations of subclinical atherosclerosis with traditional and non-traditional CV risk factors.Methods and ResultsIn a cross-sectional study, atherosclerosis burden was compared between 112 female SLE patients and 31 controls. Plaque number and carotid intima-media wall thickness (cIMT) were assessed by ultrasonography. In a retrospective study, BMD determinations obtained 5-years before the ultrasonography assessment were analyzed in a subgroup of 62 patients. Plaque frequency was increased in SLE, even in patients without CV events or carotid wall thickening. cIMT was increased in patient...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
We report a patient with SLE–AAV overlap syndrome diagnosed based on clinical, serologic and biopsy-proven histologic findings who presented with subarachnoid hemorrhage (SAH) secondary to ruptured right anterior cerebral artery aneurysm. To the authors’ knowledge, this is the first reported case of SLE–AAV overlap syndrome diagnosed in a patient with a SAH due to an intracranial aneurysm. Neurologic involvement in patients with SLE–AAV overlap syndrome is uncommon and has not been well-studie d. Clinicians who encounter patients with neurologic signs that present with symptoms and a serologic profi...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Yingjie Lu, Hongmiao Wang, Hua Zheng, Xiao LiIndian Journal of Dermatology, Venereology, and Leprology 2018 84(6):687-689 Lupus vulgaris is a common form of cutaneous tuberculosis in China, mostly involving the head and neck region. Turkey ear is a clinically descriptive term, used for a massively enlarged earlobe with bluish-red or violaceous indurated plaques and nodules, which can be a sign of lupus vulgaris. A 47-year-old female presented with edema and reddish ulcerated lesions on both ears which was diagnosed as lupus vulgaris by conventional laboratory investigations and the patient showed good response to antitube...
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research
This study aims to analyze the associations of subclinical atherosclerosis with traditional and non-traditional CV risk factors.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
More News: Drugs & Pharmacology | Lupus