Integrating endocannabinoid signaling in the regulation of anxiety and depression

Integrating endocannabinoid signaling in the regulation of anxiety and depressionIntegrating endocannabinoid signaling in the regulation of anxiety and depression, Published online: 12 July 2018; doi:10.1038/s41401-018-0051-5Integrating endocannabinoid signaling in the regulation of anxiety and depression
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research

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Authors: Wu KK, Armstrong AW Abstract Psoriasis is a chronic inflammatory skin disease with under-investigated and underappreciated links to psychiatric comorbidities, including anxiety, depression, and suicidality. In this review, we synthesize and discuss the literature investigating the association between psoriasis and three measures of suicidality: suicidal ideation, suicide attempts, and completed suicide. Studies have shown that psoriasis is significantly linked to all three measures of suicidality, but the available data on suicide attempts and completed suicides is limited and less consistent. Studied risk...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Authors: Lee B, Lee H Abstract Posttraumatic stress disorder (PTSD) is a trauma-induced psychiatric disease characterized by impaired hyperarousal, fear extermination, depression, anxiety, and amnesic symptoms that may include the release of monoamines in the dread circuit. Curcumin (CUR), a major diarylheptanoid and polyphenolic component of Curcuma longa, reportedly possesses several pharmacological features, including antidiabetic, antiatherosclerotic, anticancer, and neuropsychiatric actions. But the anxiolytic-like effects of CUR and its mechanism of action in PTSD are unclear. The current research measured so...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Abstract The current study is among the first to examine rank-order stability and mean-level change across college in both broad Big Five personality trait domains (e.g., Neuroticism) and the narrower facets underlying these domains (i.e., self-reproach, anxiety, and depression). In addition, the current study tests longitudinal associations between Big Five domains and facets and 3 aspects of adjustment: self-esteem, academic adjustment, and social adjustment in college. Specifically, the study examines codevelopment (correlated change), personality effects on later changes in adjustment, and adjustment effects o...
Source: Journal of Personality and Social Psychology - Category: Psychiatry & Psychology Authors: Tags: J Pers Soc Psychol Source Type: research
DiscussionOur results show that women long period of cancer survival have high prevalences of anxiety than depression, and this prevalence of anxiety is higher than the general population. In addition, we found inequalities between social classes and the isolation and social support are worse too in low social class.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 19 July 2018Source: NeuronAuthor(s): Xiang Nie, Shiho Kitaoka, Kohei Tanaka, Eri Segi-Nishida, Yuki Imoto, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Masayuki Taniguchi, Yuko Mimori-Kiyosue, Akira Kakizuka, Shuh Narumiya, Tomoyuki FuruyashikiSummaryRepeated environmental stress has been proposed to induce neural inflammation together with depression and anxiety. Innate immune receptors, such as Toll-like receptors (TLRs), are activated by exogenous or endogenous ligands to evoke inflammation. Here we show that the loss of TLR2 and TLR4 (TLR2/4) abolished repeated so...
Source: Neuron - Category: Neuroscience Source Type: research
Psoriasis is a chronic inflammatory skin disease with under-investigated and underappreciated links to psychiatric comorbidities, including anxiety, depression, and suicidality. In this review, we synthesize and discuss the literature investigating the ass...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Human trafficking exerts psychological effects on survivors that persist after intervention, and even after community reintegration. Effects include anxiety, depression, alienation, disorientation, aggression, suicidal ideation, attention deficit, and post...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
(JAMA Network) Physical conditions in a neighborhood matter. Trash, a lack of sidewalks and parks, and vacant or dilapidated spaces have been associated with depression, while living near green spaces has been associated with less depression, anxiety and stress. In Philadelphia, a citywide cluster randomized trial looked at whether greening vacant urban land by getting rid of trash, grading the land, planting new grass and some trees, and installing low wooden fencing could improve self-reported mental health.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We examined 10- to 13-year-old children’s eye contact processing and pupil dilation in response to happy, neutral, and angry faces in three groups: SAD (n = 31), mixed anxiety disorders (MAD; n = 30), and healthy controls (HC; n = 32). Compared to HC, SAD children showed faster first fixations on the eye region of neutral faces and shorter first fixation durations on the eye region of all faces. No differences between the two clinical groups emerged in eye movement results. SAD girls showed reduced pupil dilation in response to happy and angry faces compared to MAD and to hap...
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
Publication date: Available online 17 July 2018Source: NeuroscienceAuthor(s): Gudrun Winther, Betina Elfving, Heidi Kaastrup Müller, Sten Lund, Gregers WegenerAbstractPrenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but may involve both neuroinflammation and a dysregulated neuroendocrine stress axis. Thus, the aim of this work was to: (i) investigate the influence of maternal HFD on memory, anxiety and depression-like behavior in adult offspring and (...
Source: Neuroscience - Category: Neuroscience Source Type: research
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