Emerging role of lncRNAs in systemic lupus erythematosus.

Emerging role of lncRNAs in systemic lupus erythematosus.
Biomed Pharmacother. 2018 Jul 02;106:584-592
Authors: Zhao CN, Mao YM, Liu LN, Li XM, Wang DG, Pan HF
Abstract
Long non-coding RNAs (lncRNAs), defined as ≥200 base pairs in length but have little translation potential, play a key role in imprinting control, immune cell differentiation, apoptosis and immune responses. Recently, many potential lncRNAs have been revealed to contribute to a new layer of molecular regulation of systemic lupus erythematosus (SLE). Immune-related functional lncRNAs may serve as novel therapeutic targets and disease biomarkers to provide potential support for clinic treatment in this disease. In this review, we will briefly introduce the identification, biogenesis and functions of lncRNAs, and summarize recent advance in the role of lncRNAs in SLE.
PMID: 29990846 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Zhao CN, Mao YM, Liu LN, Li XM, Wang DG, Pan HF Tags: Biomed Pharmacother Source Type: research