Impaired ankle ‐brachial index in antiphospholipid syndrome: Beyond the traditional risk factors

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research

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A role of thrombophilia in myocardial infarction with non-obstructive coronary arteries (MINOCA) is unclear. We investigated thrombophilic factors in MINOCA patients versus those following cryptogenic stroke (CS), a well-established indication for thrombophilia screening.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
cute;rez-Martin A Abstract Malignancies can be associated with positive antiphospholipid antibodies but cancer incidence in the purely obstetric form of antiphospholipid syndrome is currently unknown. Our aim was to investigate the comparative incidence of cancers in women with a history of obstetric antiphospholipid syndrome within a referral university hospital-based cohort (NOH-APS cohort). We performed a 17-year observational study of 1592 nonthrombotic women with three consecutive spontaneous abortions before the 10th week of gestation or one fetal death at or beyond the 10th week of gestation. We compared th...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
Catastrophic antiphospholipid syndrome (CAPS) is a severe but rare form of antiphospholipid syndrome (APS) that results in multiple thrombosis of multiple organs within a week [1]. Similarly, heparin-induced thrombocytopenia (HIT) has been associated with severe and life-threatening thrombosis, both conditions mediated by an autoimmune disorder resulting in a highly thrombotic state [2,3]. Both conditions requiring aggressive therapeutic anticoagulation when coinciding CAPS complicated by HIT presents a therapeutic challenge. Current recommendations advocate for the use of anti-Xa activity monitoring in the setting of APS ...
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: CASE REPORTS Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31091357 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
CONCLUSIONS: The above data support that epigenetic alterations could be implicated in the pathophysiology of APS and prompt further investigation of their potential diagnostic or therapeutic utility. PMID: 31103268 [PubMed - as supplied by publisher]
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 11 May 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Giuseppe Benagiano, Marisa Benagiano, Paola Bianchi, Mario Milco D’Elios, Ivo BrosensAbstractAutoimmune diseases (AIDs) affect women with a 2 - 1 ratio vs. men, suggesting that hormonal contraceptives play a role in their clinical course.Combined oral contraceptives have complex, sometimes contradictory, effects on AIDs; they can worsen the situation in women with Systemic Lupus Erythematosus and with Antiphospholipid Syndrome, condition in which they are contraindicated. Early studies indi...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
This article reviews the cardiac detriments of APS, including treatment recommendations for each cardiac complication.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: In older individuals followed longitudinally, aPL do not relate to cognitive or motor decline, inflammation, or cerebrovascular disease on in vivo neuroimaging or postmortem neuropathology.Neuroepidemiology
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10-15% have a manifestation of secondary APS. Animal studies suggested that complement activation plays an important role in the pathophysiology of thrombosis and pregnancy loss in APS. We performed a cross-sectional study on complement proteins and genes in 525 patients with aPL. Among them, 237 experienced thromboses and 293 had SLE; 111 had both SLE and thromboses, and 106 had neither SLE nor thrombosis. Complement protein levels were determined by radial immu...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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