Impaired ankle ‐brachial index in antiphospholipid syndrome: Beyond the traditional risk factors

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research

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Authors: Skeith L Abstract Antiphospholipid syndrome (APS), heparin-induced thrombocytopenia, and paroxysmal nocturnal hemoglobinuria are 3 acquired thrombophilias that carry a high risk of venous and arterial thromboembolism. Management of these conditions has largely included anticoagulation with a vitamin K antagonist after an initial period of a parenteral anticoagulant, for as long as the thrombotic risk is still present. The available evidence for the use of direct oral anticoagulants (DOACs) is limited and primarily consists of case series and cohort studies, which are summarized in this chapter. Randomized ...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Authors: Gansner JM, Berliner N Abstract Catastrophic antiphospholipid antibody syndrome (CAPS) and macrophage activation syndrome (MAS) are both life-threatening hematologic disorders that infrequently afflict patients with rheumatologic disease. CAPS is characterized by fulminant multiorgan damage related to small vessel thrombosis in the setting of persistent antiphospholipid antibodies. It can occur in patients with rheumatologic diseases such as systemic lupus erythematosus but can also affect patients who do not have rheumatologic disease. By contrast, the term MAS is applied when patients with rheumatologic ...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
We report an ischemic stroke patient using an oral contraceptive with aPS/PT complex antibody.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
AbstractObjectiveTo validate the association of thrombotic events with positive lupus anticoagulant (LA) and co-presence of anti-RNP/Sm, as well as the diagnostic accuracy of this combination of antibodies for thrombosis.MethodsCase-control study of patients with systemic lupus erythematosus (SLE) who presented thrombosis after SLE diagnosis and controls with SLE without thrombosis. Comorbidities, traditional risk factors, clinical variables, and treatment were evaluated. Antiphospholipid (aPL) and anti-RNP/Sm antibodies were determined.ResultsSixty-three cases and 63 controls were studied, 88% women, median age of 40 &nbs...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
FRIDAY, Nov. 30, 2018 -- There is a strong and independent association between the presence of antiphospholipid antibodies (aPLs) and first-time myocardial infarction (MI), according to a research letter published recently in the Annals of Internal...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Just when you thought your brain could unwind on a Friday! Time to GUESS THE DISEASE challenge for Funtabulously Frivolous Friday Five 261 The post Funtabulously Frivolous Friday Five 261 appeared first on Life in the Fast Lane.
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: FFFF antiphospholipid syndrome APS Benjamin Sacks Catastrophic APS Cyclophosphamide Emanuel Libman endocarditis Glucocorticoids IVIG Libman-Sacks endocarditis Livedo reticularis plasma exchange Salmonella shrinking lung syndrom Source Type: blogs
In neuromyelitis optica spectrum disorders (NMOSD), the clinical and long-term prognostic value of antinuclear antibodies (ANAs) is unclear. We analyzed registry data of NMO-IgG seropositive NMOSD patients (n  = 74) according to ANA presence. The ANA-positive group (n = 32) demonstrated more frequent other autoantibodies (anti-SSA/Ro, anti-SSB/La, antiphospholipid, and anti-double stranded DNA antibodies) than did the ANA-negative group (n = 42). Clinically, annual relapse rates, and average lesion extents on MRI during attacks were comparable between the two groups (median follow-up of 7 years).
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Tags: Short Communication Source Type: research
Thomas Fleetwood, Roberto Cantello, CRISTOFORO COMI
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Antiphospholipid syndrome (APS), heparin-induced thrombocytopenia, and paroxysmal nocturnal hemoglobinuria are 3 acquired thrombophilias that carry a high risk of venous and arterial thromboembolism. Management of these conditions has largely included anticoagulation with a vitamin K antagonist after an initial period of a parenteral anticoagulant, for as long as the thrombotic risk is still present. The available evidence for the use of direct oral anticoagulants (DOACs) is limited and primarily consists of case series and cohort studies, which are summarized in this chapter. Randomized trials evaluating DOACs in patients...
Source: Blood - Category: Hematology Authors: Tags: Thrombosis and Hemostasis, Review Articles Source Type: research
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