Basal cell carcinoma of the scrotum: A rare occurrence in sun protected skin
ConclusionBCC should be considered in the elderly with chronic skin lesions at the genitalia. Multiple factors contribute to delayed presentation.
Mrs. S is an 85-year-old woman who moved into the nursing home five years ago when her husband could no longer provide care for her due to her progressive weakness and failure to thrive. She has a history of Barrett ’s esophagus and significant reflux and subsequent dysphagia, a long history of depression, allergic rhinitis, dementia with a Brief Interview for Mental Status (BIMS) score of 12, basal cell carcinoma, insomnia, iron deficiency anemia, and a pneumonitis due to aspiration. She is oxygen dependent.
This study was undertaken to identify risk factors using the UNOS database.
We thank van Delft et al. for their letter to the Editor related to our published European consensus-based interdisciplinary guidelines on the diagnosis and treatment of basal cell carcinoma (BCC) . They comment on the extensive safety margins for conventional (2D) surgical excision of high-risk BCCs and the prop osed frequent follow-up of patients with a history of BCC.
Condition: Basal Cell Carcinoma of the Head and Neck Interventions: Drug: Pembrolizumab; Other: Tissue collection Sponsor: Brian Gastman Not yet recruiting
No abstract available
In conclusion, this study has revealed notable BCC tumor microenvironment findings associated with important clinical features. Microenvironment-altering agents may be used locally for "routine" BCCs and systematically for advanced or resistant BCCs. PMID: 32198729 [PubMed - as supplied by publisher]
CONCLUSIONS A 3-mm surgical margin may be sufficient and safe for BCC excision.
We report the case of a 71-year-old woman who developed advanced basal cell carcinoma (BCC) affecting the right eyebrow, invading the orbit. Globe displacement resulted in visual disturbances. Following multidisciplinary assessment, the tumour was deemed technically resectable for excision and right orbital exenteration. The patient however refused ablative surgical treatment; in view of her multiple comorbidities, the tumour was considered unresectable for her. Targeted therapy with vismodegib (Erivedge; Roche Pharmaceuticals) was therefore initiated in accordance with the patient ’s desire to avoid disfiguring surgery.
ConclusionsWhile CVID patients are at increased risk for lymphoma, lymphoproliferation may be observed in the absence of a concurrent hematologic or solid tumor malignancy.
Keratocystic odontogenic tumors (KCOTs) are locally aggressive odontogenic neoplasms with recurrence rates of up to 60%. Approximately 5% of KCOTs are associated with nevoid basal cell carcinoma (Gorlin) syndrome and 90% of these show genomic inactivation of the PTCH1 gene encoding Patched 1. Sporadic KCOTs reportedly have PTCH1 mutations in 30% of cases, but previous genomic analyses have been limited by low tumor DNA yield. The aim of this study was to identify recurrent genomic aberrations in sporadic KCOTs using a next-generation sequencing panel with complete exonic coverage of sonic hedgehog (SHH) pathway members PTC...