Adrenergic- and non-adrenergically-mediated human adipose tissue lipolysis during acute exercise and exercise training

Obesity-related adipose tissue dysfunction, in particular subcutaneous adipose tissue (SCAT) lipolysis, is characterized by catecholamine resistance and impaired ANP responsiveness. It remains unknown whether exercise training improves (non-)adrenergically-mediated lipolysis in metabolically compromised conditions. We investigated the effect of local combined α-/β-adrenoceptor blockade on abdominal SCAT lipolysis in lean insulin sensitive (IS, n=10), obese IS (n=10) and obese insulin resistant (IR, n=10) men. Obese men participated in a 12-week exercise training intervention to determine the effects on SCAT lipolysis. Abdominal SCAT extracellular glycerol concentration and blood flow (ATBF) were investigated using microdialysis, with/without local combined α-/β-adrenoceptor blockade at rest, during low-intensity endurance-type exercise and post-exercise recovery. In obese IR men, microdialysis was repeated after exercise intervention. The exercise-induced increase in SCAT extracellular glycerol was more pronounced in obese IS versus lean IS men, possibly resulting from lower ATBF in obese IS men. The exercise-induced increase in extracellular glycerol was blunted in obese IR versus obese IS men, despite comparable local ATBF. Abdominal SCAT extracellular glycerol was markedly reduced (remaining ~60% of exercise-induced SCAT extracellular glycerol) following local α-/β-adrenoceptor blockade in obese IS but not in IR men, suggesting reduced cate...

Source: Clinical Science - July 6, 2018 Category: Biomedical Science Authors: Verboven, K., Stinkens, R., Hansen, D., Wens, I., Frederix, I., Eijnde, B. O., Jocken, J. W., Goossens, G. H., Blaak, E. E. Tags: PublishAheadOfPrint Source Type: research