Effectiveness of antifungals decreased by oncology drugs

Effectiveness of antifungals decreased by oncology drugsThu, 07/05/2018 - 14:10News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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The objective of the study was to identify molecularly-isolated strains of Aspergillus from patients with invasive aspergillosis (IA); these strains were primarily typed as Aspergillus fumigatus sensu lato by conventional phenotypic methods. We worked with 20 strains from the mycology section of the Institute of Tropical Medicine "Daniel A. Carrión." To obtain the fungal DNA, thermal shock, enzymatic treatment, and silica gel column techniques were used; and it was stored at -20°C to preserve it. The real-time polymerase chain reaction (qPCR) procedure included fluorochrome-labeled primers, which ampli...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Soghra Khani, Sima Sadat Seyedjavadi, Hadi Zare-Zardini, Hamideh Mahmoodzadeh Hosseini, Mehdi Goudarzi, Shohreh Khatami, Jafar Amani, Abbas Ali Imani Fooladi, Mehdi Razzaghi-AbyanehAbstractThe increasing resistance of pathogenic fungi to conventional antifungal therapies is a major global health concern. Currently, antifungal peptides are receiving increasing attention as suitable candidates for antifungal drug discovery. In the present study, an antifungal peptide was isolated from Satureja khuzistanica by reverse phase-HPLC column and sequenced by ...
Source: Phytochemistry - Category: Chemistry Source Type: research
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Letter To The Editor Source Type: research
Authors: Antonogiannaki EM, Proklou A, Tamiolakis D, Vassalou E, Kondili E Abstract Invasive Aspergillus tracheobronchitis is a relatively rare form of invasive pulmonary aspergillosis characterized by invasion of the tracheobronchial tree by Aspergillus spp. Invasive pulmonary aspergillosis is predominantly detected in severely immunocompromised patients. Notably however, pulmonary and tracheobronchial cases of invasive aspergillosis have also been reported, particularly in the context of severe malaria caused by Plasmodium falciparum. Herein, we present a case of invasive Aspergillus tracheobronchitis in a patien...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.8b01066
Source: Journal of Natural Products - Category: Biochemistry Authors: Source Type: research
This article describes 3 cases of IPA. Two patients had a history of chronic obstructive pulmonary disease (COPD) and asthma, and the other patient had no underlying diseases. The Aspergillus fumigatus gene was found in the bronchoalveolar lavage fluid in all three cases by NGS. This report explores the role of NGS in the diagnosis of IPA and emphasizes that IPA may occur in non-neutropenic patients. PMID: 31105860 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
In conclusion, we provide an integrated picture of the metabolic and regulatory aspects of the interaction of A. fumigatus and dendritic cells during infection.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, we functionally characterized the FgMed1, a gene encoding an ortholog of a conserved MedA transcription factor known to be a key conidiogenesis regulator in Aspergillus nidulans. The gene deletion mutants ΔFgMed1 produced significantly less conidia, and these were generated from abnormal conidiophores devoid of phialides. Additionally, we observed defective sexual development along with reduced virulence and deoxynivalenol (DON) production in ΔFgMed1. The GFP-tagged FgMed1 protein localized to the nuclei of conidiophores and phialides during early conidiogenesis. Significantly, RNA-Seq analyses s...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
Abstract Aspergillus fumigatus is a saprophytic mold that can cause infection in patients with impaired immunity or chronic lung diseases. The polysaccharide-rich cell wall of this fungus is a key point of contact with the host immune system. The availability of purified cell wall polysaccharides and mutant strains deficient in the production of these glycans has revealed that these glycans play an important role in the pathogenesis of A. fumigatus infections. Herein, we review our current understanding of the key polysaccharides present within the A. fumigatus cell wall, and their interactions with host cells and...
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Tags: Curr Opin Microbiol Source Type: research
e Piñar Salt mines are among the most extreme environments as they combine darkness, low nutrient availability, and hypersaline conditions. Based on comparative genomics and transcriptomics, we describe in this work the adaptive strategies of the true halophilic fungus Aspergillus salisburgensis, found in a salt mine in Austria, and compare this strain to the ex-type halotolerant fungal strain Aspergillus sclerotialis. On a genomic level, A. salisburgensis exhibits a reduced genome size compared to A. sclerotialis, as well as a contraction of genes involved in transport processes. The proteome of A. sclerotialis...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
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