Validating the portal population of the United Kingdom Multiple Sclerosis Register

Publication date: August 2018Source: Multiple Sclerosis and Related Disorders, Volume 24Author(s): R.M. Middleton, W.J. Rodgers, J. Chataway, K. Schmierer, D. Rog, I. Galea, A. Akbari, K. Tuite-Dalton, H. Lockhart-Jones, D. Griffiths, D.G. Noble, K.H. Jones, A. Al-Din, M. Craner, N. Evangelou, P. Harman, T. Harrower, J. Hobart, H. Husseyin, M. KastiAbstractThe UK Multiple Sclerosis Register (UKMSR) is a large cohort study designed to capture ‘real world’ information about living with multiple sclerosis (MS) in the UK from diverse sources. The primary source of data is directly from people with Multiple Sclerosis (pwMS) captured by longitudinal questionnaires via an internet portal. This population's diagnosis of MS is self-reported and therefore unverified. The second data source is clinical data which is captured from MS Specialist Treatment centres across the UK. This includes a clinically confirmed diagnosis of MS (by Macdonald criteria) for consented patients.A proportion of the internet population have also been consented at their hospital making comparisons possible. This dataset is called the ‘linked dataset’. The purpose of this paper is to examine the characteristics of the three datasets: the self-reported portal data, clinical data and linked data, in order to assess the validity of the self-reported portal data.The internet (n = 11,021) and clinical (n = 3,003) populations were studied for key shared characteristics. We found them t...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Publication date: Available online 4 June 2020Source: NeuroImage: ClinicalAuthor(s): Sandra González-Villá, Arnau Oliver, Yuankai Huo, Xavier Lladó, Bennett A. Landman
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 4 June 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Kevin Yan, Chakrapani Balijepalli, Kamal Desai, Lakshmi Gullapalli, Eric Druyts
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 4 June 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Jan Kolcava, Jan Kocica, Monika Hulova, Ladislav Dusek, Magda Horakova, Milos Kerkovsky, Jakub Stulik, Marek Dostal, Matyas Kuhn, Eva Vlckova, Josef Bednarik, Yvonne Benesova
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: August 2020Source: Multiple Sclerosis and Related Disorders, Volume 43Author(s): Zuhal Abasıyanık, Asiye Tuba Özdoğar, Özge Sağıcı, Turhan Kahraman, Cavid Baba, Özge Ertekin, Serkan Özakbaş
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
In this study, we selected semaphorin-3A (Sema3A), semaphorin-7A (Sema7A), and their receptors to determine the possible relationship between these molecules and multiple sclerosis (MS). METHOD: We measured the gene expression of Sema3A, Sema7A, neuropilin-1 (NP-1), plexin-C1, and β1 integrin in the blood samples of relapsing-remitting multiple sclerosis (RRMS) patients, treated with high-dose interferon-β1a (IFN-β1a), low-dose IFN-β1a, IFN-β1b, and glatiramer acetate (GA) via quantitative real-time polymerase chain reaction (qRT-PCR) assay, and then, compared the results of treatment-naive pat...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Authors: Anagnostouli M, Markoglou N, Chrousos G Abstract Multiple sclerosis (MS) is a multifactorial, chronic, immune-mediated, and neurodegenerative disease, having a well-known hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Several hormones have a great impact in the immune dysregulation, psychology, and cognitive status of patients with MS, as also in the fertility and response to treatment. In this comprehensive review, as an introduction, we mention basic data concerning MS: epidemiology, genetics, immunogenetics, epigenetics, pathophysiology, and neuroimmunology. Hormonal components of the disease ca...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
We report herein a case of bloodstream infection due to LM in a 25-year-old woman with MS treated with alemtuzumab. We searched the UMC/WHO Vigibase system for all reported cases of LM in patients treated with alemtuzumab and found 29 cases overall up to 21 July 2019. We also performed a literature review of MS cases with LM on alemtuzumab, in order to evaluate epidemiology, clinical characteristics, and outcome of this complication. Since the published cases (N=8) were mainly reported in recent years but more cases were found in the UMC/WHO Vigibase system (although not necessarily in patients with MS), we hypothesize tha...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Activation of the T cell receptor (TCR) results in binding of the adapter protein Nck (noncatalytic region of tyrosine kinase) to the CD3ϵ subunit of the TCR. The interaction was suggested to be important for the amplification of TCR signals and is governed by a proline-rich sequence (PRS) in CD3ϵ that binds to the first Src homology 3 (SH3) domain of Nck (Nck-SH3.1). Inhibition of this protein/protein interaction ameliorated inflammatory symptoms in mouse models of multiple sclerosis, psoriasis, and asthma. A small molecule, AX-024, was reported to inhibit the Nck/CD3ϵ interaction by physically binding to the Nck1-SH3....
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Protein Structure and Folding Source Type: research
A review of FDA reports also shows notably higher rates of shingles in women among younger patients taking disease-modifying therapies for multiple sclerosis.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Source Type: news
CONCLUSION: The results of this experiment suggest the possibility of swimming exercise in urological diseases that are difficult to treat. Swimming exercises can be considered for relief of symptom in incurable multiple sclerosis. PMID: 32482056 [PubMed]
Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
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