Application of small molecule CHIR99021 leads to the loss of hemangioblast progenitor and increased hematopoiesis of human pluripotent stem cells

Hematopoietic differentiation of human pluripotent stem cells (hPSCs) Furthermore, it provides reciprocal knowledge for understanding the hematopoietic specification of various blood lineages [1 –8]. Although the derivation of various types of hematopoietic cells from hPSCs has been achieved, the generation of HSCs remains an ongoing pursuit [9,10]. Because only definitive hematopoiesis generates HSCs, most efforts are directed at enhancing definitive commitment. The embryonic origin of p rimitive and definitive hematopoiesis has been widely discussed and reviewed [11,12].

Source: Experimental Hematology - June 4, 2018 Category: Hematology Authors: Yekaterina Galat, Irina Elcheva, Svetlana Dambaeva, Dimantha Katukurundage, Kenneth Beaman, Philip M. Iannaccone, Vasiliy Galat Source Type: research