New guidelines to treat endocrine disorders in childhood cancer survivors
The new Endocrine Society Clinical Practice Guideline, published in theJournal of Clinical Endocrinology& Metabolism, advises how to diagnose and treat endocrine disorders that affect up to 50% of childhood cancer survivors.Science Daily
Funding Opportunity PAR-19-069 from the NIH Guide for Grants and Contracts. REISSUE of PAR-18-733 The NIH Common Fund has established the Gabriella Miller Kids First Pediatric Research Program (Kids First) to develop a pediatric research data resource populated by genome sequence and phenotype data that will be of high value for the communities of investigators who study the genetics of childhood cancers and/or structural birth defects. The overall goal of the Gabriella Miller Kids First Pediatric Data Resource is to help researchers understand the underlying mechanisms of these conditions, leading to more refined diagnos...
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ConclusionsOur data provide pre-clinical information that can be incorporated into future early-phase clinical trials for the assessment of carfilzomib as a treatment for children with refractory hematological malignancies.
AbstractThe aetiology of childhood cancers remains largely unknown. Space –time clustering of cases might imply an aetiological role of infections. We aimed to review the evidence of space–time clustering of specific childhood cancers. We searched Medline and Embase for population-based studies that covered a pre-defined study area, included cases under 20 years of a ge and were published before July 2016. We extracted all space–time clustering tests and calculated the proportion of positive tests per diagnostic group. In a pooled analysis, we performed a Knox test of the number of pairs of cases clo...
Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP), Published online: 15 November 2018; doi:10.1038/s41408-018-0150-zCorrespondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP)
(ECCO-the European CanCer Organisation) Researchers investigating new treatments for neuroblastoma -- one of the most common childhood cancers -- have found that a combination of two drugs made tumors disappear in mice, making it more effective than any other drugs tested in these animals. The research is presented at the 30th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland.
In conclusion, we documented that promoter methylation can act as the first 'hit' in Knudson's model. This mosaic epimutation mimics the effect of an inactivating mutation and phenocopies RB onset.This article is protected by copyright. All rights reserved
AbstractObjectiveThe intensive and long ‐lasting experience of childhood cancer is a tremendous stressor for the parental relationship. We aimed to i) compare civil status and partner relationship of parents of long‐term childhood cancer survivors with population‐based comparisons, ii) identify cancer‐related characteristics assoc iated with not‐being‐married, and iii) evaluate the quality of the partner relationship.MethodsWe sent questionnaires to parents of survivors aged ≤16 years at diagnosis and ≥20 years at study. Population‐based comparisons were derived from a random sample of the general popul...
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