Unique role of epicardial adipose tissue in atrial fibrosis: ‘Atrial remodeling of a new sort’

Pivotal studies over the last few decades have identified the important role of electrical and structural remodeling in different atrial fibrillation (AF) substrates.1 More recently, epicardial adipose tissue (EAT) has emerged as an important pro-arrhythmic substrate for AF and may in part explain the clinical association between obesity and AF.2, 3 Expansion of EAT, which often occurs as a consequence of weight gain, has been shown to predict greater risk for AF development and severity, as well as poorer outcomes following rhythm control strategies.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research

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Atrial fibrillation (AF) is a frequently identified arrhythmia during the course of sepsis. The aim of this narrative review is to assess the characteristics of patients with new-onset AF related to sepsis and the risk of stroke and death, to understand if there is a need for anticoagulation. We searched for studies on AF and sepsis on PubMed, the Cochrane database, and Web of Science, and 17 studies were included. The mean incidence of new-onset AF in patients with sepsis was 20.6% (14.7% in retrospective studies and 31.6% in prospective). Risk factors for new-onset AF included advanced age, white race, male sex, obesity,...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
CONCLUSIONS: Māori and Pacific people experience the most significant inequities in exposure to CVD risk factors compared with other ethnic groups. Indians have a high prevalence of diabetes and coronary heart disease. Strong political commitment and cross-sectoral action to implement effective interventions are urgently needed. PMID: 32994634 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Obesity and excessive visceral adiposity has been considered a key mediator in metabolic and cardiovascular diseases. In previous studies we demonstrated the impact of Bariatric Surgery (BS) on cardiovascular health and function. The aim of this study is to report the changes in interatrial fat (IAF) after bariatric surgery and its effect on the risk of developing new onset atrial fibrillation (Afib).
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Bariatric and Foregut Source Type: research
Conditions:   Atrial Fibrillation;   Obesity Interventions:   Behavioral: Physician-lead complex program of weight-reducing interventions;   Procedure: Bariatric surgery - sleeve gastrectomy Sponsor:   Martin Haluzik Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Palpation initially confirms the findings of inspection and further looks for new findings. Apex beat: Apex beat is defined as the lowest and outer most point of definite cardiac impulse. If apex beat is not felt on left side, immediately check on right side or else we might miss a dextrocardia. There some who even palpate both sides simultaneously for this reason. Apex beat is initially felt with the palm of the hand and then localized with the index finger. Sometimes it may be difficult to palpate in obese individuals and in those with emphysema. Palpation in held expiration and in the left lateral position may help in...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: HBC Source Type: blogs
Semin Thromb Hemost DOI: 10.1055/s-0040-1714400Atrial fibrillation (AF) is a frequently identified arrhythmia during the course of sepsis. The aim of this narrative review is to assess the characteristics of patients with new-onset AF related to sepsis and the risk of stroke and death, to understand if there is a need for anticoagulation. We searched for studies on AF and sepsis on PubMed, the Cochrane database, and Web of Science, and 17 studies were included. The mean incidence of new-onset AF in patients with sepsis was 20.6% (14.7% in retrospective studies and 31.6% in prospective). Risk factors for new-onset AF includ...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Tags: Review Article Source Type: research
We report the case of a 71 ‐year‐old obese continuous positive airway pressure (CPAP)‐treated man who developed an acute cardiac failure (ACF) triggered by atrial fibrillation. CPAP data downloaded from the CPAP software (Rescan®) retrospectively demonstrated the progressive development of a high residual central apnoe a–hypopnoea index (AHI) with Cheyne–Stokes respiration (CSR). The AHI decreased after cardioversion allowing normalization of cardiac rhythm and function. Raw data extracted from CPAP software showed a gradual decrease in the periodic breathing cycle length related to a simultaneous imp...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Conclusions: This large matched-cohort study identified the minimum weight loss thresholds for reduction in risk of MACE and all-cause mortality in patients with obesity and diabetes. Furthermore, in our analysis, the effect of surgery was still present after accounting for weight loss, which may suggest the presence of weight-independent beneficial effects of metabolic surgery on MACE and survival.
Source: Annals of Surgery - Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE AMERICAN SURGICAL ASSOCIATION Source Type: research
Bariatric surgery is a mainstay of treatment for obesity, and results in anatomic changes which may influence pharmacokinetic properties of medications.1 –3 Atrial fibrillation (AF) is a common comorbidity among the bariatric surgery population as obesity itself increases the risk of developing AF and often requires anticoagulation. To date there is limited evidence describing the efficacy and safety of oral anticoagulants in patients with bariatri c surgery, and even less to guide agent selection when therapy is warranted.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
ConclusionsBariatric surgery can be safely performed in patients on therapeutic anticoagulation, though this population is at greater risk for bleeding complications in the perioperative period. Meticulous hemostasis in the operating room is the most important aspect of preventing bleeding complications.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
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