Delayed sleep-wake phase disorder and delayed sleep-wake phase in schizophrenia: Clinical and functional correlates

Growing evidence suggests that circadian rhythm disruption is detrimental to health. A link between clock genes, circadian rhythm disruption and dopamine dysregulation has been shown in schizophrenia (Yates, 2016). In a recent report (Wulff et al., 2012), two profiles of sleep disturbance in schizophrenia were identified. The first profile was characterized by delayed or non-24-hour sleep-wake phase, sleep onset difficulty, prolonged sleep, and reduced daytime activity, while the other had normal non-shifted entrained rhythms, sleep onset difficulty, and excessively prolonged, irregular or fragmented sleep.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research