Scientists create artificial ovary giving hope to infertile women
A synthetic organ – made out of the woman's own tissue – could be transplanted into a female left infertile due to medical treatment. She could then go on to produce eggs naturally.
There is rapidly growing interest in uterine transplantation for the management of uterine factor infertility (UFI). Recent experimental procedures have demonstrated that women with congenital or acquired absence of a uterus can become pregnant and give birth to a child after a successful uterine transplant, with the first birth occurring in 2015 . The procedure was once considered only in theory, remaining a unique intersection of reproductive and transplant medicine that had never been undertaken.
Authors: Padela AI, Clayville K PMID: 30040553 [PubMed - in process]
Authors: Bruno B, Arora KS Abstract Research teams have made considerable progress in treating absolute uterine factor infertility through uterus transplantation, though studies have differed on the choice of either deceased or living donors. While researchers continue to analyze the medical feasibility of both approaches, little attention has been paid to the ethics of using deceased versus living donors as well as the protections that must be in place for each. Both types of uterus donation also pose unique regulatory challenges, including how to allocate donated organs; whether the donor / donor's family has any...
Conditions: Mrk Anomaly; Infertility, Female Intervention: Procedure: uterus transplantation surgery and IVF Sponsors: Sahlgrenska University Hospital, Sweden; Saint Joseph University, at Bellevue Medical Centre Recruiting
ConclusionsEvidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research.
Conditions: Absolute Uterine Factor Infertility; Transplantation; Mrk Anomaly Intervention: Procedure: uterus transplantation Sponsor: Sahlgrenska University Hospital, Sweden Enrolling by invitation