Scientists create artificial ovary giving hope to infertile women

A synthetic organ – made out of the woman's own tissue – could be transplanted into a female left infertile due to medical treatment. She could then go on to produce eggs naturally.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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CONCLUSIONS: The ways in which women with AUFI conceptualize this condition in their lives and choices around UTx and participating in a study of the procedure are multifaceted and textured. These perspectives are critical to understanding its ethical, legal, and social implications. PMID: 30855220 [PubMed - as supplied by publisher]
Source: AJOB Primary Research - Category: Medical Ethics Tags: AJOB Empir Bioeth Source Type: research
(Abstracted from Science 2018;362:356–360) Studies have shown that mouse pluripotent stem cells (PSCs) can be induced into primordial germ cell–like cells (hPGCLCs), which, following transplantation under appropriate conditions, can contribute to the development of gametes capable of developing into fertile offspring. Human in vitro gametogenesis from PSCs has long-reaching implications in reproductive medicine but has not yet been achieved.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES Source Type: research
(Abstracted from Hum Reprod 2018;33:2249–2255) Cytotoxic cancer treatments, including chemotherapy and radiotherapy, cause damage to spermatogenic stem cells (SSCs), jeopardizing the fertility of young men of reproductive age. One potential method for future production of sperm in this population is SSC transplantation.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES Source Type: research
Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregna...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Over 10% of new cancer diagnoses occur in reproductive aged women, impacting 87 per 100,000 women each year [1]. Improvement in the management and treatment of these patients is leading to improved survival [2] and greater interest in survivorship outcomes. There is a growing movement to preserve the fullness of cancer patients ’ future. Satisfactory quality-of-life in cancer survivors may include the ability to conceive children and the infertility associated with cancer treatment can contribute to profound distress and depression in survivors [3].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Hematopoietic cell transplantation (HCT) is the only established curative therapy for sickle cell disease (SCD). Rates of disease-free survival exceed 95% with a matched-sibling donor using myeloablative conditioning.1 However, busulfan-based conditioning regimens are associated with substantial morbidity and high rates of infertility, particularly in adolescent females; recipients over 16 years of age have poorer outcomes.1,2 Graft-versus-host disease (GVHD) remains a challenge and a major reason why not all children and adolescents with a matched sibling donor are offered HCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Hematopoietic cell transplantation (HCT) is the only established curative therapy for sickle cell disease (SCD). Rates of disease-free survival exceed 95% with a matched sibling donor (MSD) using myeloablative conditioning (MAC) [1]. However, busulfan-based conditioning regimens are associated with substantial morbidity and high rates of infertility, particularly in adolescent females; recipients older than 16 years of age have poorer outcomes [1,2]. Graft-versus-host disease (GVHD) remains a challenge and a major reason not all children and adolescents with an MSD are offered HCT [1,2].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
cute; Abstract Systemic lupus erythematosus is the most characteristic of auto-immune disorders that can lead to tissue damage in many organs, including kidney. Lupus nephritis occurs in 10 to 40% of lupus patients. Its clinical hallmark is the appearance of a proteinuria as soon as a 0.5 g/g or 0.5 g/d threshold, which calls for a renal histological evaluation in order to determine the lupus nephritis severity and the need for specific therapy. More than half of renal biopsies lead to the diagnosis of active lupus nephritis-class III or class IV A according to the ISN/RPS classification-t...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
Authors: Zaami S, Di Luca A, Marinelli E Abstract Women suffering from Uterine Factor Infertility (UFI) arising from congenital conditions (e.g., Rokitansky-Kuster-Hauser syndrome) or hysterectomy can fulfill their wish to achieve motherhood only by resorting to surrogacy, which is, however, banned in most countries. Medical research has long been looking into uterus transplant (UTx), which may constitute a valuable alternative for such patients. Following decades of animal testing and clinical trials, several successful pregnancies have been carried to term. Yet UTx is still to be considered as an experimental pro...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Survivors of hematopoietic cell transplantation (HCT) often face infertility later in life due to preparative conditioning regimens that are harmful to reproductive function. Current American Society of Clinical Oncology (ASCO) clinical guidelines on fertility preservation (FP) recommend that all patients who are at risk for infertility due to medical treatment should be referred to a fertility specialist for counseling following diagnosis and preferably prior to the start of treatment. Despite HCT physicians ’ awareness of standard-of-care services for preserving fertility and the psychosocial sequelae resulting fro...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 85 Source Type: research
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