OCUM Trial: Some Rectal Cancers Need Only Surgery OCUM Trial: Some Rectal Cancers Need Only Surgery

The German study used MRI to help distinguish between high- and low-risk rectal cancers, which, in turn, dictated treatmentMedscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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Authors: Holck S, Klarskov LL, Larsson LI Abstract Treatment of rectal cancer has been vastly improved by advances in surgery and radiochemotherapy but remains an important cause of morbidity and mortality worldwide. A particular problem is the lack of predictive markers that can help to individualize treatment. The growth- and apoptosis-regulating signaling molecules ERK 1 and 2 are important to cancer growth and progression. They are activated through phosphorylation, which is initiated by a cascade involving the EGF receptor and RAS as upstream regulators. Moreover, in vitro studies indicate that phospho-ERKs in...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We describe methods to improve dose delivery for patients with rectal cancer receiving boost brachytherapy after external beam radiotherapy.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Authors: Komen N, Dewint P, Van den Broeck S, Pauli S, de Schepper H Abstract The field of rectal cancer treatment is a dynamic and changing field, due to better understanding of the pathology and new medical treatment options, but perhaps mostly due to innovations in the surgical approach. Surgery is the cornerstone for rectal cancer treatment. Currently, Total Mesorectal Excision is the gold standard. After evolution towards laparoscopic TME, improving technology has led to the development of platforms that allow transanal TME and robotic TME. In addition, local excision can be performed safer and more accurately...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
AbstractSeveral systematic reviews have investigated the accuracy of imaging modalities for lymph node involvement of rectal cancer, but there are considerable differences in conclusions. This overview aimed to assess the methodological and reporting quality of systematic reviews that evaluated the diagnostic value of imaging modalities for lymph node involvement in patients with rectal cancer and to compare the diagnostic value of different modalities for lymph node involvement. The PubMed, EMBASE, Cochrane Library and Chinese Biomedicine Literature were searched to identify relevant systematic reviews. The methodological...
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
ConclusionsTB has prognostic value as important as lymph node involvement and radial margin status and it may be a helpful prognostic indicator even after CRT. TB should be included in the TNM classification and may be used in planning adjuvant therapy.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
URMC is only the sixth institution in the country and the only one in New York and the Northeast to receive this accreditation so far.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news
(Champalimaud Centre for the Unknown) When rectal cancer infiltrates lymph nodes, patients may have better clinical outcome if chemo/radiotherapy are administered before surgery. However, the lymph nodes' status can only be precisely assessed upon removal during this same surgery. To find a way out of this 'Catch,' a multidisciplinary team, developed an MRI methodology, called SPI, that identifies infiltrated lymph nodes. SPI can help define treatment strategy for rectal cancer patients and may have future implications for other malignancies.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Despite clinical guidelines classifying T2 rectal cancer as a contraindication for transanal local excision attributable to unacceptably high rates of local recurrence, it is a practice that persists clinically. Recent clinical trials have suggested that transanal local excision in addition to neoadjuvant chemoradiation is an acceptable alternative in select patients.
Source: Surgery - Category: Surgery Authors: Source Type: research
Authors: Fujikawa H, Toiyama Y, Inoue Y, Omura Y, Ide S, Kitajima T, Yasuda H, Okugawa Y, Okita Y, Yoshiyama S, Hiro J, Kobayashi M, Ohi M, Araki T, Kusunoki M Abstract The present study designed a novel preoperative chemoradiotherapy (CRT) with sequential oxaliplatin and irinotecan with S-1 for locally advanced rectal cancer (LARC). This phase I study evaluated the maximum tolerated dose and recommended dose (RD) of oxaliplatin following irinotecan with S-1. Patients with clinical stage T3 or 4 or involvement of the regional nodes and no evidence of distant metastases were treated with fixed doses of S-1 (80 mg/m2...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
ConclusionsThis study shows that the nationwide structured training program for TaTME delivers safe implementation of TaTME in terms of intraoperative and pathology outcomes within the first ten consecutive cases in each center. However, postoperative morbidity is substantial even within a structured training pathway and surgeons should be aware of the learning curve of this new technique.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
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