Determination Whether Supplemental Application of Luteotrophic Factors (Prostaglandin E2 and Chorion Gonadotropin) Support Equine Corpus Luteum Function: In Vivo and In Vitro Studies

Mechanisms controlling development and function of equine corpus luteum (CL) may involve factors produced within and outside this gland. Progesterone (P4), a main hormone produced by CL, is necessary for pregnancy establishment and maintenance. In mares, gestation depends not only on the support of P4 but also on other luteotrophic factors such as prostaglandins (PGs). PGE2 a known luteotrophic factor, stimulates the P4 production by luteal steroidogenic cells in many species. Chorionic gonadotropin (CG) has luteinizing hormone-like activity, playing important roles in regulation of CL and endometrial functions.
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research