Breath volatile organic compounds of lung transplant recipients with and without chronic lung allograft dysfunction
Introduction. Chronic lung allograft dysfunction with its clinical correlative of bronchiolitis
obliterans syndrome (BOS) remains the major limiting factor for long-term graft survival. Currently
there are no established methods for the early diagnosis or prediction of BOS. To assess the
feasibility of breath collection as a non-invasive tool and the potential of breath volatile organic
compounds (VOC) for the early detection of BOS, we compared the breath VOC composition between
transplant patients without and different stages of BOS. Methods. 75 outpatients (25 BOS stage 0, 25
BOS stage 1 + 2, 25 BOS stage 3) after bilateral lung transplantation were included. Exclusion
criteria were active smoking, oxygen therapy and acute infection. Patients inhaled room air through
a VOC and sterile filter and exhaled into an aluminum reservoir tube. Breath was loaded directly
onto Tenax ® TA adsorption tubes and was subsequently analyzed by gas-chromatography/mass-...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: L K üppers, O Holz, S Schuchardt, J Gottlieb, J Fuge, M Greer and J M Hohlfeld Source Type: research
More News: Bone Graft | Bronchiolitis | Lung Transplant | Organic | Smokers | Transplant Surgery | Transplants