Amantadine (Symmetrel, Lysovir) may be out of stock due to manufacturing delays

Anyone currently taking amantadine, sometimes prescribed for fatigue in MS, may want to check with their pharmacist to ensure there will be stocks ready for their next prescription.
Source: Multiple Sclerosis Trust - Category: Neurology Source Type: news

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Facial pain – an interdisciplinary challenge Swiss Dent J. 2020 Apr 06;(4):321-327 Authors: Gierthmuehlen M, Gierthmuehlen P, Hugger A, Gierthmuehlen J, Tuerp JC Abstract Acute pain has a warning function and is necessary to survive. Conversely, chronic or recurrent pain is a pathological entity itself and has tremendous impact on the quality of life of the patients . Facial pain is very common and can have various causes. The trigeminal nerve innervates the face, and tumours along its intracranial way as well as peripheral injury can lead to facial pain. Also, infections and systemic diseases, l...
Source: Schweizer Monatsschrift fur Zahnmedizin - Category: Dentistry Tags: Swiss Dent J Source Type: research
Authors: Dell'Aquila A, Sciatti E, Vizzardi E, Metra M Abstract We hereby report a puzzling case of multiple sclerosis (MS) relapse presenting as Takotsubo syndrome (TTS). Female, 42-years old, who presented herself to the Emergency Room of University Hospital "ASST Spedali Civili" of Brescia, Italy, for a severe headache and a non-ST-segment elevation acute coronary syndrome. Coronary angiogram showed no signs of coronary atherosclerosis. Upon further neurological evaluation, a diagnosis of MS relapse, related to TTS, was made, and treatment was started accordingly. The patient was discharged after 12 da...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
ConclusionsPLEX is a safe and effective treatment for acute attacks of DDCNS. EDSS score at admission and early clinical improvement with PLEX were factors associated with good response to PLEX.
Source: Neurological Sciences - Category: Neurology Source Type: research
AbstractPurpose of ReviewNeurotrophic keratopathy (NK) is a challenging ophthalmological disease. In this review, we present an updated evidence-based summary on the pathophysiology, classification, diagnosis, and how novel therapies have changed the management of NK.Recent FindingsNew specific medical and surgical modalities are emerging, such as Cenegermin (Oxervate ®, Dompé) and neurotization procedures, which are changing the paradigm of the treatment of NK. In addition, more diagnostic resources are available, such as corneal confocal microscopy in vivo, non-contact esthesiometers, and common ocular surface...
Source: Current Ophthalmology Reports - Category: Opthalmology Source Type: research
ConclusionsRelapse rates with treatment with FTY, DMF and TERI were similar. Patients treated with DMF showed less sustained disability progression for 12  weeks than FTY-treated patients. However, FTY and DMF treatment was associated with more likely EDSS regression for 12 and 24 weeks and a lower probability for treatment interruption as compared to TERI-treated patients.
Source: Journal of Neurology - Category: Neurology Source Type: research
Abstract The aim of this study was to investigate the demographic and clinical characteristics of patients with multiple sclerosis (MS) diagnosed between 1986 and 2015. 333 patients with definite MS were divided into four subgroups according to the following diagnostic criteria: Group A) Poser (n = 145), Group B) McDonald 2000 (n = 66), Group C) McDonald 2005 (n = 62), and Group D) McDonald 2010 (n = 60). We investigated: 1) patient sex and age at diagnosis, 2) symptoms and number of relapses that prompted MS diagnosis, 3) time between first symptoms suggestive of MS and confirmed diagnosis, and 5) Expanded Disabi...
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Tags: Neurol Neurochir Pol Source Type: research
AbstractPurposeManual measures such as corpus callosum index, normalized corpus callosum area, and width of the third ventricle are potential biomarkers for brain atrophy. In this work, we investigate their suitability to assess the neurodegenerative component of multiple sclerosis (MS) by comparing them to volumetric measures and expanded disability status scale (EDSS).MethodsFifty-eight patients with a clinically isolated syndrome, 48 MS patients treated with interferon β, and 26 treated with natalizumab underwent a brain MRI at baseline and after 1 year. Manual measures were evaluated by two observers usi...
Source: Neuroradiology - Category: Radiology Source Type: research
Nature Reviews Neurology, Published online: 03 April 2020; doi:10.1038/s41582-020-0356-0Trigeminal neuralgia linked to demyelination in multiple sclerosis
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
In this study, we tested the presence of MOG-Ab and AQP4-Ab in 57 children at first onset of acute neurological symptoms; three clinical subgroups were identified: 12 patients had acquired inflammatory demyelinating CNS syndromes, 11 had other auto immune/immune-mediated disorders of the central and peripheral nervous system and 34 had non-immune-mediated CNS disorders. MOG-Abs were found positive only in a subset of cases in the subgroup with acquired inflammatory demyelinating CNS syndromes (in 2/12 patients, both with non-MS phenotype) and in none of the patients with other autoimmune and immune-mediated disorders of th...
Source: Neurological Sciences - Category: Neurology Source Type: research
In conclusion, oculomotor impairment is a common component of disability in MS patients and should be considered when managing this type of patients. More research is still needed to know the real impact of this disease on binocular vision and accommodation. PMID: 32228341 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research
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