Penicisteroid C: New polyoxygenated steroid produced by co-culturing of Streptomyces piomogenus with Aspergillus niger

Publication date: October 2018 Source:Steroids, Volume 138 Author(s): Ahmed S. Abdel-Razek, Abdelaaty Hamed, Marcel Frese, Norbert Sewald, Mohamed Shaaban Penicisteroid C, a new polyoxygenated steroid was isolated from co-cultivation of Streptomyces piomogenus AS63D and Aspergillus niger using solid-state fermentation on rice medium. Additional diverse eleven known metabolites were identified: Fumigaclavine C, fumiquinazoline C, physcion, methylsulochrin, methyllinoleate, glycerol linoleate, cerebroside A, thymine, adenine, thymidine and adenosine. The structure of penicisteroid C was determined by HRESIMS, 1D and 2D NMR data. The antimicrobial and in vitro cytotoxic activities of the microbial extract and penicisteroid C were reported as well. Graphical abstract
Source: Steroids - Category: Drugs & Pharmacology Source Type: research