P-275Selective internal radiation therapy (SIRT) with yttrium-90 microspheres and peri-procedural FOLFIRI/irinotecan in pre-treated colorectal liver metastases patients: An analysis of outcomes from a UK Cancer Centre between 2009 and 2017

Introduction: Selective Internal Radiation Therapy (SIRT) involves hepatic intra-arterial infusion of β-particle emitting Yttrium-90 labelled microspheres. SIRT increases first line response rates (RR) and hepatic progression free survival (hPFS) in liver predominant metastatic colorectal cancer (mCRC) patients treated with oxaliplatin/5FU/folinic acid (FOLFOX). SIRT is often used in pre-treated mC RC patients with peri-procedural FOLFOX to achieve radio-sensitization and control extra-hepatic disease. Since 2009 we have used FOLFIRI as an alternative peri-procedural regimen with SIRT.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research