IgA nephropathy: new insights into the role of complement

Glomerular complement deposition is common in IgA nephropathy, and recent genome-wide association studies point to a role of complement factor H and complement factor H –related proteins in disease susceptibility. A number of recent studies have now documented elevated levels of some factor H–related proteins in IgA nephropathy, which might contribute to enhanced complement activation.

Source: Kidney International - June 20, 2018 Category: Urology & Nephrology Authors: J ürgen Floege, Mohamed R. Daha Tags: Commentary Source Type: research