Late onset diabetes may be sign of pancreatic cancer

The onset of diabetes in people over 50 years old may be an indicator of pancreatic cancer, according to research published in theJournal of the National Cancer Institute.CNN
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Publication date: July 2018Source: The American Journal of Surgery, Volume 216, Issue 1Author(s): Hans G. Beger, Benjamin MayerAbstractThe metrics for measuring early postoperative morbidity after resection of pancreatic neoplastic tumors are overall morbidity, severe surgery-related morbidity, frequency of reoperation and reintervention, in-hospital, 30-day and 90-day mortality and length of hospital stay. Thirty-day readmission after discharge is additionally an indispensable criterion to assess quality of surgery. The metrics for surgery-associated long-term results after pancreatic resections are survival times, new on...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: May 2018Source: Advances in Biological Regulation, Volume 68Author(s): Saverio Candido, Stephen L. Abrams, Linda Steelman, Kvin Lertpiriyapong, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Matilde Y. Follo, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Pann-Gill Suh, Massimo Libra, James A. McCubreyAbstractPancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10% after diagn...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
ConclusionCA 19–9 levels after a diagnosis of new-onset DM could be a useful biomarker of pancreatic cancer, especially in patients with high serum bilirubin.
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
Publication date: October 2017Source: Best Practice &Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Murray Korc, Christie Y. Jeon, Mouad Edderkaoui, Stephen J. Pandol, Maxim S. Petrov, on behalf of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)AbstractPancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this arti...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Conclusions Poor glycemic control and weight loss, particularly in combination, may be useful early markers for PaC in patients with long-standing diabetes.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
ConclusionIn this study, T2DM patients were shown to have higher crude IRs of liver, pancreatic and colon cancer, but not of gastric, biliary, and rectal cancer. Moreover, the lower observed IRs of oesophageal cancer in diabetic patients warrants further investigation.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
New-onset diabetes mellitus (DM) is one of the first symptoms of pancreatic adenocarcinoma (PDAC). The frequency of endocrine disorders is estimated between 40% and 80% in patients with pancreatic cancer. DM is a risk factor for cancer development but it may also be a consequence of the tumor growth. Data confirming the existence of a relationship between long standing type 2 DM and an increased risk of PDAC comes from numerous clinical studies. Insulin resistance phenomenon and hyperinsulinemia may result in the increased proliferation of pancreatic islets which in turn may cause a predisposition to cancer development. In...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: Clinical Reviews Source Type: research
(Washington State University) A new study conducted at Washington State University has brought scientists closer to finding out why working night shifts increases your risk of developing diabetes and other metabolic disorders. The study revealed that just three days of being on a night shift schedule will disrupt metabolism. This disruption appears to be driven by separate biological clocks (so-called peripheral oscillators) in the liver, gut and pancreas, rather than the brain's master clock.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
AbstractRisk of cancer especially of colon, breast, and pancreas is high in diabetic and obese patients, with potential involvement of augmented expression of RAGE (receptor for advanced glycation end products) and its ligands, namely AGEs (advanced glycation end products), HMGB1 (high-mobility group box 1 protein), and S100 group of proteins. Studies have reported the involvement of RAGE activation by its ligands in growth and survival of cancers, including metastasis and poor prognosis. We propose that this receptor-ligand axis provides the molecular link between certain pre-existing states as hypoxia, hyperglycemia, gly...
Source: Hormones and Cancer - Category: Cancer & Oncology Source Type: research
A risk-stratification score identifies which patients with new-onset diabetes are at high risk of having pancreatic cancer and should receive a clinical workup.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
More News: Cancer | Cancer & Oncology | Diabetes | Endocrinology | Pancreas | Pancreatic Cancer