Molecules, Vol. 23, Pages 1472: Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease

This study provides the first account of a 3-alkylpyridinium complex that exhibits a proposed antiviral activity by inhibiting the NS3 protease. We suggest that the here-described compound can be further modified to increase its stability and tested in a cell-based assay to explore its full potential as a potential novel antiviral capable of inhibiting WNV replication.

Source: Molecules - June 18, 2018 Category: Chemistry Authors: Aubrie O ’Rourke Stephan Kremb Brendan M. Duggan Salim Sioud Najeh Kharbatia Misjudeen Raji Abdul-Hamid Emwas William H. Gerwick Christian R. Voolstra Tags: Article Source Type: research