Mayo Clinic discovery is first step toward new bacteria-based constipation treatment

ROCHESTER, Minn. ? Genetically engineered bacteria are showing promise as a new treatment for constipation, researchers at the Mayo Clinic Center for Individualized Medicine have discovered in a mouse study. The finding is significant in part because there are few approved constipation remedies on the market. The research is published in Cell Host&Microbe. [...]
Source: Mayo Clinic Minnesota News - Category: Hospital Management Source Type: news

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Condition:   Constipation - Functional Interventions:   Drug: PEG 3350;   Drug: Lactulose Sponsors:   Fakultas Kedokteran Universitas Indonesia;   PT Meiji Indonesia Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, there were no significant differences in the efficacies of QUEIR600, QUEIR300, and QUEXR300 in treating bipolar depression; moreover, tolerance to QUEIR600 might be worse than the other treatments.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Digital rectal examinations can save time and money in diagnosing and treating constipation, but they are too often avoided.Medscape Medical News
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Gastroenterology News Source Type: news
Authors: Vijayvargiya P, Camilleri M Abstract INTRODUCTION: Prucalopride is a selective 5-HT4 receptor agonist with colonic prokinetic activity. It was recently approved by the FDA for the treatment of chronic idiopathic constipation. Before this approval, there were limited options to improve colonic motility in the treatment of chronic idiopathic constipation. Areas covered: We systematically searched PubMed, Embase, ClinicalTrials.gov, and international conference presentations, and we reviewed all studies that evaluated prucalopride for the treatment of chronic idiopathic constipation in adults. In this review,...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
We describe the protocol for a randomized, patient-assessor-blinded, sham controlled trial. Seventy-two eligible patients will be randomly assigned to the intervention group (acupuncture) or the control group (sham acupuncture). All treatment will be given 26 sessions of acupuncture or sham acupuncture over 8 weeks (5 times per week in the first 2 weeks, 3 times per week during weeks 3-6, and 2 times per week during weeks7 and 8). Each treatment will last for 20 minutes. The primary outcome is the change in mean complete spontaneous bowel movements (CSBMs) per week. The secondary outcomes are patient assessment of constipa...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
MiraLAX is a brand-name, over-the-counter product that ’s typically used to treat short-term constipation. It contains polyethylene glycol 3350, which also comes as store-branded generic products. MiraLAX comes as a powder that you mix with liquid to drink. Learn about side effects, warnings, dosage, and more.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Constipation Source Type: news
Publication date: Available online 15 May 2019Source: Surgery (Oxford)Author(s): Narin Suleyman, Freddie CL. BanksAbstractThe initial management of bladder outflow obstruction typically related to benign prostatic hyperplasia (BPH) falls to a large extent within the remit of general practice. Referral onwards to secondary care typically arises following the failure to respond to conservative measures or when complications have supervened; the most significant of which is urinary retention. In the hospital setting, anaesthesia, constipation and immobility are the common precipitants. What follows is a practical guide to the...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
Conclusion: The new field of pediatric PFPT is a safe and effective intervention for children with dyssynergic defecation causing or contributing to chronic constipation, particularly in  children whose comorbidities include anxiety and low ­muscle tone.Dig Dis
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
ConclusionsMultiple myeloma has myriad presentations. Gastrointestinal involvement, although rare, can manifest as small bowel obstruction for which early recognition and appropriate surgical management are key to improving outcome. Intussusception is the most common mechanism of obstruction from extramedullary plasmacytoma causing small bowel obstruction and this has been seen in five of six case reports, including this case. It is important to recognize and consider the risks of immunosuppression, venous thromboembolism, and malnutrition in the surgical management of gastrointestinal complications of multiple myeloma.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Authors: Lang-Illievich K, Bornemann-Cimenti H Abstract Pain therapy often entails gastrointestinal adverse events. While opioids are effective drugs for pain relief, the incidence of opioid-induced constipation (OIC) varies greatly from 15% to as high as 81%. This can lead to a significant impairment in quality of life, often resulting in discontinuation of opioid therapy. In this regard, a good doctor-patient relationship is especially pivotal when initiating opioid therapy. In addition to a detailed history of bowel habits, patient education regarding the possible gastrointestinal side effects of the drugs is cr...
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
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