Mount Sinai team diagnoses asthma with nasal brush test

(The Mount Sinai Hospital / Mount Sinai School of Medicine) Mount Sinai researchers have identified a genetic biomarker of asthma that can be tested for using a simple nasal brush and basic follow-up data analysis. This inexpensive diagnostic test can accurately identify mild to moderate asthma and differentiate it from other respiratory conditions.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Abstract Mast cells are key effector cells in inflammatory and allergic immune responses such as asthma, rhinitis, and atopic dermatitis. Activation of mast cells leads to immediate release of preformed mediators such as histamine and proteases, which can regulate vascular permeability and the function of a number of immune and nonimmune cells. Engineered nanomaterials (ENM) have been utilized for a wide range of applications and introduced into a number of consumer products; yet the consequent increase in human exposure and any potential adverse effects have not been fully evaluated. Modulation of the immune syst...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Phyllanthin and hypophyllanthin from Phyllanthus amarus ameliorates immune-inflammatory response in ovalbumin-induced asthma: role of IgE, Nrf2, iNOs, TNF-α, and IL's. Immunopharmacol Immunotoxicol. 2018 Dec 12;:1-13 Authors: Wu W, Li Y, Jiao Z, Zhang L, Wang X, Qin R Abstract BACKGROUND: Asthma is a chronic airway immunoinflammatory disorder characterized by airway remodeling. Phyllanthus amarus has been reported to possess antioxidant and anti-inflammatory potential. AIM: To evaluate the possible mechanism of action of isolated phytoconstituents from P. amarus (PA) against ovalbumin (OVA)-i...
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
ConclusionsOur results suggest that metformin users are more likely to initiate preventive therapies and engage in other healthy behaviors. Failure to account for these behaviours may introduce healthy user bias into studies evaluating the effect of oral antidiabetic therapies.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Asthma risk also increased with maternal history of miscarriages at 12 weeks or earlier
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Gynecology, Pathology, Pediatrics, Pulmonology, Allergy, Journal, Source Type: news
Publication date: January 2019Source: Molecular Immunology, Volume 105Author(s): Edy Yong Kim, William M. OldhamAbstractRapid onset of acute inflammation is a hallmark of critical illnesses that bring patients to the intensive care unit (ICU). In critical illness, innate T cells rapidly reach full activation and drive a robust acute inflammatory response. As “cellular adjuvants,” innate T cells worsen inflammation and mortality in several common critical illnesses including sepsis, ischemia-reperfusion injury, stroke, and exacerbations of respiratory disease. Interestingly, innate T cell subsets can also promot...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Authors: Singh N, Kulkarni GT, Kumar Y Abstract AIM AND BACKGROUND: The rationale of this study is that, treatment of asthmatic Guinea pig with combined administration of Montelukast sodium and green tea extract (GTE) as a single capsule will mitigate the inflammatory injury in the airways and weaken the asthmatic response. Recent patents for the treatment of asthma researched a polyphenolic alternatives for antiasthmatic combination therapy, especially for those patients who remains unresponsive or poorly responsive for current asthma therapy (US7232585B2). Synergistic activity of green tea polyphenols and therape...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research
Dr Ramesh Kurukulaaratchy, from University Hospital Southampton NHS Trust, was one of the scientists behind the app - available on Google Play and the Apple App Store.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
FRIDAY, Dec. 14, 2018 -- Parental subfertility is associated with an increased asthma risk among offspring, according to a study published online Dec. 4 in Thorax. Maria Christine Magnus, Ph.D., from the Norwegian Institute of Public Health in Oslo,...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
(Children's National Health System) A small percentage of women said they consumed fewer allergens during pregnancy to stave off food allergies in their newborns, according to preliminary research Karen Robbins, M.D., presented during the American College of Asthma Allergy and Immunology 2018 Annual Scientific Meeting.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusions: The present study concludes that there is increased candidal growth among asthmatics as compared to their normal healthy counterpart.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
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