Respiratory Pathogens May Up Treatment Failure Risk in Asthma

THURSDAY, June 7, 2018 -- Respiratory pathogens are associated with increased risk of treatment failure in children with asthma exacerbations, according to a study published online June 4 in Pediatrics. Joanna Merckx, M.D., from Montreal Children's...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Fanciful flavors added to e-cigarettes react with vaping solvents (eg, polypropylene glycol) to create compounds that may persist and harm.
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Asthma Source Type: news
Authors: Skrzypek M, Kowalska M, Kobza J, Wypych A, Czech EM, Niewiadomska E, Bała MM Abstract OBJECTIVE: The aim of the study was to estimate changes in the prevalence of respiratory diseases and disorders between 2003/2004 and 2011/2012 in 13-16 years old children living in Bytom, one of the biggest cities in the Silesia agglomeration and provide the evidence for local policy makers. METHODS: Data from two cross-sectional surveys, based on the Polish version of the International Study of Allergy and Asthma in Childhood (ISAAC) questionnaire, conducted in 2003/2004 and 2011/2012 was used. Response rate in the...
Source: Central European Journal of Public Health - Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research
Conclusions: The use of e-health tools in mass screening and new media to conduct information and education campaigns allows for the reduction of costs and for efficient implementation of activities. It is important to popularize the use of this type of solutions both at national and local level. PMID: 30416810 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Zhang JF, Li Y, Zhang AZ, He QQ, Du YC, Cao W Abstract Background: Cigarette smoking aggravates the symptoms of asthma, leading to the rapid decline of lung function. Dendritic cells (DCs) and lymphocytes are considered initiating and promoting factors for the airway inflammation reactions of asthma. In addition, activation of CC chemokine receptor 7 (CCR7) by chemokine (C-C motif) ligand (CCL) 19 and 21 promotes DCs and T cells migration to lymphoid tissues during inflammation. We aimed to examine how cigarette smoke affects the expression of CCR7 in the lungs of asthmatic rats and explore the signaling m...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
This study included 831,613 patients and 16,804 institutions in the analysis. The overall mean ICS prescription rate was 22.58%. Tertiary hospitals had the highest mean prescription rate (84.16%) whereas primary healthcare clinics had the lowest (20.71%). By specialty, internal medicine physicians prescribed ICS more frequently compared to other specialists. Of all, 47.17% of medical institutions prescribed ICS to 80% of asthma patients. Also, we found that female and patients with age>90 or
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
CONCLUSIONS: MHT could mitigate the pathological changes of acute asthma-like syndrome through inhibition of the TLR9 pathway. Results of this study may provide a reference for the development of a novel therapy for patients with allergic asthma. PMID: 30415587 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Conclusion: The overexpression of miR-200a may downregulate FOXC1, thereby inhibiting the activation of the PI3K/AKT signaling pathway and ultimately suppressing ASMC proliferation and airway remodeling in asthmatic mice. This evidence supports the potential that miR-200a represents a new approach to treating asthma.Cell Physiol Biochem 2018;50:2365 –2389
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Allowing insurance companies to exclude preexisting conditions from health insurance coverage could cost consumers with illnesses like asthma, arthritis, cancer, diabetes, and high blood pressure thousands of dollars in increased out-of-pocket costs, according to a Commonwealth Fund report by Sherry Glied and Adlan Jackson of New York University. In a related post, the Commonwealth Fund's Sara Collins explains that some Republican proposals, such as the Ensuring Coverage for Patients with Pre-Existing Conditions Act, would erode ACA protections. Even thought the bill would prevent insurers from refusing to sell a plan to ...
Source: The Commonwealth Fund: Publications - Category: International Medicine & Public Health Source Type: research
Authors speculate that this alteration of smooth airway muscle may imprint a unique signature that could help lead to highly targeted new asthma therapies.
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Asthma Source Type: news
(MedPage Today) -- Also, reasons to start an asthma initiative
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
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