Effect of prostaglandin reductase 1 (PTGR1) on gastric carcinoma using lentivirus-mediated system Retraction.
Effect of prostaglandin reductase 1 (PTGR1) on gastric carcinoma using lentivirus-mediated system [Retraction]. Int J Clin Exp Pathol. 2018;11(3):1838 Authors: Abstract [This retracts the article on p. 14493 in vol. 8, PMID: 26823768.]. PMID: 29874340 [PubMed - in process]
kavous Parang We have previously reported cyclic cell-penetrating peptides [WR]5 and [WR]4 as molecular transporters. To optimize further the utility of our developed peptides for targeted therapy in cancer cells using the redox condition, we designed a new generation of peptides and evaluated their cytotoxicity as well as uptake behavior against different cancer cell lines. Thus, cyclic [C(WR)xC] and linear counterparts (C(WR)xC), where x = 4–5, were synthesized using Fmoc/tBu solid-phase peptide synthesis, purified, and characterized. The compounds did not show any significant cytotoxicity (at 25 µ...
In the Netherlands, neoadjuvant chemoradiotherapy (nCRT) has become standard treatment for non-metastic resectable esophageal cancer as it increases survival compared to surgery alone. Stenosis of the cervical anastomosis is a common postoperative complication after gastric tube reconstruction requiring endoscopic dilations. We hypothesized that radiation dose on the future anastomotic region (FAR) was related to the occurrence and severity of the anastomotic stenosis. We evaluated the incidence of stenosis and analyzed risk factors associated with severity of the stenosis.
With the advancement in endoscopic equipment, superficial carcinoma of the esophagogastric junction is more frequently detected and more likely to be treated with endoscopic treatment in recent years than in previous years in Japan. However, it is difficult to diagnose the lateral extension of esophagogastric cancer when these lesions extend under the squamous epithelium. Although cancer under the squamous epithelium (CUS) of Barrett's esophageal cancer (BC) is well-known, the CUS of gastric cardiac cancer (GC) remains largely unclear.
Objective: Colorectal endoscopic submucosal dissection (ESD) is now carried out mainly by endoscopists with sufficient experience in gastric ESD. However, the detection rate of early gastric carcinoma is still low in China and endoscopic maneuverability differs between the stomach and colorectum. The aim of this study was to assess the feasibility of colorectal ESD carried out by endoscopists with no or little experience in gastric ESD.
This study analyzed the clinical implications and risk factors for high-grade adenoma or carcinoma in patients with biopsy proven gastric RA.
A 65 year old male with a history of HIV (CD4: 347), COPD, hypertension, and anal squamous cell carcinoma status post diverting colostomy, and adjuvant chemoradiation developed recurrent small bowel obstruction (SBO) requiring ileocecectomy with ileocolonic anastomosis. Following an extended admission at our institution for SBO with failure of conservative treatment, the patient was taken to the operating room for surgical management with laparotomy and lysis of adhesions; a gastrostomy tube was placed at that time for gastric decompression.
Gastric adenomas are neoplastic with similar microscopic findings to those seen in colonic adenomas. Around 8-59% of gastric adenomas are associated with synchronous gastric carcinoma and hence repeat upper endoscopic surveillance after one year is usually recommended. On the other hand, the data has been scarce and inconsistent with regards to their association with colonic polyps and colorectal cancer. We aimed to analyze the previously published literature evaluating the association between gastric neoplasm and colonic polyps and colorectal cancer.
Epstein-Barr Virus (EBV)-associated gastric cancer (EBVGC) accounts for approximately 10% of gastric cancers. EBVGC is classified into one of the four molecular subtypes proposed by The Cancer Genome Atlas Research Network (Nature, 2014), and there have been reports which imply the relatively low risk of lymph node metastasis (LNM) in EBVGC with submucosal invasion (pT1b-EBVGC). However, a large cohort study is still lacking.
An amendment to this paper has been published and can be accessed via the original article.
ConclusionsConsuming fresh fruit more than 12 times/year may reduce the long ‐term risk of ESCC mortality in this dysplasia population, particularly in females, non‐smokers, and nondrinkers. Future studies are needed to confirm these findings.