Evaluation of tumor-infiltrating lymphocytes using routine H & E slides predicts patient survival in resected non-small cell lung cancer

The presence of tumor-infiltrating lymphocytes (TILs) positively impacts the outcome of non-small cell lung cancer (NSCLC) patients. Most previous studies have assessed TILs using different immunohistochemical assays. The purpose of this study was to develop and validate a histopathological scoring model for the assessment of TILs in whole tissue hematoxylin and eosin (H&E)-stained section slides of NSCLC patients and to evaluate the model in an immunoscore setting. Therefore, TIL was evaluated manually on H&E slides from 537 surgical specimens of primary resected stage I-III NSCLC patients.

Source: Human Pathology - June 6, 2018 Category: Pathology Authors: Mehrdad Rakaee, Thomas K. Kilvaer, Stig Manfred Dalen, Elin Richardsen, Erna-Elise Paulsen, Sigurd M. Hald, Samer Al-Saad, Sigve Andersen, Tom Donnem, Roy M. Bremnes, Lill-Tove Busund Tags: Original Contributions Source Type: research