Alanine-Glyoxylate Aminotransferase 1 (AGXT1) is a Novel Marker for Hepatocellular Carcinomas

Arginase-1 has been demonstrated as a marker for hepatocellular carcinoma with higher sensitivity and specificity than HepPar-1 and glypican-3. However, its sensitivity is diminished in moderately and poorly differentiated hepatocellular carcinomas. In current study, we evaluated the utility of AGXT1 as a diagnostic marker. Immunostains for AGXT1 and arginase-1 were performed in tissue microarrays of 139 hepatocellular carcinomas (HCCs) and 374 gastrointestinal and non-gastrointestinal carcinomas.

Source: Human Pathology - June 5, 2018 Category: Pathology Authors: Chaohui Lisa Zhao, Yiang Hui, Li Juan Wang, Dongfang Yang, Evgeny Yakirevich, Shamlal Mangray, Chiung-Kuei Huang, Shaolei Lu Tags: Original Contributions Source Type: research