Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo

ConclusionKLHL3 expression was decreased in CUL3WT/ Δex9 mice. However, expression levels of other KLHL family proteins were comparable between the wild-type and mutant mice. These findings indicate that the decreased abundance of KLHL3 is a specific phenomenon caused by mutant CUL3 ( Δexon9). Our findings would improve our understanding of the pathogenesis of PHAII caused byCUL3 mutation in vivo.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research