Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry.

Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry.
Annu Rev Nutr. 2018 May 31;:
Authors: Wessling-Resnick M
Abstract
Because both the host and pathogen require iron, the innate immune response carefully orchestrates control over iron metabolism to limit its availability during times of infection. Nutritional iron deficiency can impair host immunity, while iron overload can cause oxidative stress to propagate harmful viral mutations. An emerging enigma is that many viruses use the primary gatekeeper of iron metabolism, the transferrin receptor, as a means to enter cells. Why and how this iron gate is a viral target for infection are the focus of this review. Expected final online publication date for the Annual Review of Nutrition Volume 38 is August 21, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 29852086 [PubMed - as supplied by publisher]

Source: Annual Review of Nutrition - May 31, 2018 Category: Nutrition Authors: Wessling-Resnick M Tags: Annu Rev Nutr Source Type: research