Role of 18F-Fluorocholine PET-CT and ROLL guided by ultrasound in primary hyperparathyroidism with no evidence of lesions in conventional diagnostic protocol. Preliminary results

1436Objectives:Preoperative ultrasonography and 99mTc-sestaMIBI are commonly used to localize abnormal parathyroid glands. When these procedures failed in the detection of lesions it is important to rely on another diagnostic imaging modalities. 18F-FDG and 11C-methionine have been studied, but are imperfect to detect abnormal parathyroid glands. We have evaluated the role of 18F-Fluorocholine (FCH) PET-CT in the detection of parathyroid adenoma in patients with primary hyperparathyroidism with negative or inconclusive ultrasound and Tc99m-sestaMIBI SPECT-CT prior to radioguided surgery (ROLL guided by ultrasound) based on information from FCH PET-CT.We included four patients with primary hyperparathyroidism and with negative results on preoperative ultrasonography and 99mTc-sestamibi dual-phase scintigraphy. Cervical PET scan was performed 10-15 minutes after injection of 18F-Fluoromethylcholine (3 MBq/kg) using intravenous contrast. Not dynamic early images were acquired. ROLL guided by ultrasound was performed based on FCH uptake findings and the results of PET-CT were confirmed histopathologically in all cases. Mean calcium and PTH levels prior to surgery were 2.76 ± 0.17 mmol/l and 94.8 ± 37.4 ng/l. FCH PET/CT was positive in all cases. Mean lesion size was 13.1 ± 8.6 mm and all patients underwent radioguided surgery (ROLL technique) . The day before surgery an intralesional dose of 99mTc-MAA was injected guided with ultrasound based on FCH PET-CT fi...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Head and Neck Posters Source Type: research