Effects of multi-day ethanol intoxication on post-burn inflammation, lung function, and alveolar macrophage phenotype - Curtis BJ, Boe DM, Shults JA, Ramirez L, Kovacs EJ.

Burn patients who consumed alcohol prior to injury have worse clinical outcomes, including longer hospital stays, increased ventilator days, and more respiratory infections. Most alcohol consumers are binge drinkers and not chronic alcoholics and binge dri...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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Publication date: Available online 21 May 2019Source: Physiology &BehaviorAuthor(s): Alissa A. Nolden, Gabrielle Lenart, John E. HayesAbstractCapsaicin is classically considered an irritant, due to the warming and burning sensations it elicits. Widespread consumption of chilis suggests many individuals enjoy this burn, but these sensations can be overwhelming if the burn is too intense. While substantial folklore exists on the ability of specific beverages to mitigate capsaicin burn, quantitative data to support these claims are generally lacking. Here, we systematically tested various beverages for their ability to re...
Source: Physiology and Behavior - Category: Physiology Source Type: research
This study e...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
Publication date: Available online 4 May 2019Source: BurnsAuthor(s): Catherine Adams, Connell Locke, James WarnerAbstractObjectiveTo describe the epidemiology of patients assessed by a Psychiatric Liaison Team (PLT) on a Regional Burns Unit in London, UK.MethodA case note review of all patients assessed by the PLT over a 4-year period was carried out. Data were extracted regarding whether the burn was sustained intentionally or non-intentionally, ICD-10 psychiatric diagnosis, alcohol use at the time of injury and mechanism of injury. The independent t-test and chi-squared test were used for data analysis.ResultsThe PLT ass...
Source: Burns - Category: Dermatology Source Type: research
This study aimed to describe the epidemiology of severe burn injuries admitted to burn centres in Australia and New Zealand.Materials and methodsData from the Burns Registry of Australia and New Zealand (BRANZ) were used in this study. Patients were eligible for inclusion if they were admitted between August 2009 and June 2013, were adults (18-years or older), and had burns of 20% total body surface area (TBSA) or greater. Demographics, burn characteristics and in-hospital mortality risk factors were investigated using multivariable Cox proportional hazards analysis.ResultsThere were 496 BRANZ registered patients who met t...
Source: Burns - Category: Dermatology Source Type: research
Conclusion Massive SI and immune cell paralysis associated with ACLF represent the extreme severity of CAID in response to an infectious or sterile challenge. The severe immune disturbance plays a pivotal role in the pathogenesis of the distinctive features of ACLF: organ failure and bacterial infection susceptibility. Excessive SI in ACLF results from the massive activation and dysfunction of an innate immune system challenged by increased PAMPs and DAMPs. SI leads to cell and tissue immunopathology contributing to hepatic and extrahepatic organ failure. Concomitantly, the course of ACLF is associated with a disproportio...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Hongfei Gu1†, Shuang Shao2†, Jie Liu3,4,5, Zhenqian Fan2, Yu Chen2, Jingxian Ni3,4,5, Conglin Wang6, Jun Tu3,4,5, Xianjia Ning3,4,5, Yongzhong Lou1*, Bin Li1* and Jinghua Wang3,4,5* 1Department of Neurology, Tianjin Haibin People's Hospital, Tianjin, China 2Department of Endocrinology and Metabolism, The Second Hospital of Tianjin Medical University, Tianjin, China 3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China 4Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, China 5Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
LAKEWOOD, Colo. (AP) — A truck driver blamed for causing a deadly pileup involving over two dozen vehicles near Denver has been arrested on vehicular homicide charges. Videos: Colorado Fiery, Fatal Pileup Lakewood police spokesman Ty Countryman said Friday that there’s no indication that drugs or alcohol played a role in Thursday’s crash on Interstate 70. The unidentified driver was headed down a hill when he slammed into slower traffic and sparked a massive fire. Countryman said police are looking at whether his brakes were working. Countryman said 28 vehicles were involved, up from the initial 15 vehicl...
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Tags: Major Incidents News Mass Casualty Incidents Source Type: news
We examined the expression of TRPV1 in peripheral tissue and DRG neurons of CPIP model rats and we studied whether CPIP model could induce peripheral sensitization of TRPV1 channel and enhance DRG neuron excitability. Then we examined the therapeutic effects of locally applied TRPV1 specific antagonist AMG9810 on pain responses of CPIP model rats. Lastly, we explored the effects of AMG9810 on DRG neuron hyperexcitability and spinal glial activation induced by CPIP. Our results demonstrate that TRPV1 plays an important role in mediating the behavioral hypersensitivity of CPIP model rats via promoting peripheral nociceptor a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Soon-Hwan Oh1, Brooke Smith2, Andrew N. Miller3, Bart Staker4, Christopher Fields5, Alvaro Hernandez5 and Lois L. Hoyer1* 1Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States 2Department of Biology, Millikin University, Decatur, IL, United States 3Illinois Natural History Survey, Urbana, IL, United States 4Seattle Structural Genomics Center for Infectious Disease, Seattle Children’s Hospital, Seattle, WA, United States 5Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL, United States The agglutinin-like sequence (Als)...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusions This study revealed important information about the use of testing measures in FASD assessment and sheds light on the commonalities in practice across clinics in Alberta. Results demonstrate strong convergence of direct and indirect measures to assess brain function. Ultimately, identifying a comprehensive, reliable, and usable testing battery of measures for FASD assessment will improve the clarity and accuracy of the diagnostic process and facilitate advancements in the field, as well as enable comparisons across clinics. PMID: 31002487 [PubMed - in process]
Source: Journal of Population Therapeutics and Clinical Pharmacology - Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research
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